The RNA alphabet is {A,G,C,U}. There are 412 "words" of length 12 that can be formed from this 4-letter alphabet. On the assumption each letter occurs in Nature with equal probability (p = 0.25), the information content associated with such a word is
log2(412) =

log2(224) =

24 bits.

However, in Nature the actual genetic instructions arise not from this alphabet, but from the 20-letter amino acid code alphabet, each letter of which is associated with an ordered triple from the RNA alphabet (plus three to signify the end of a gene).