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NBio46b : The Neurobiology of Sleep and Dreaming

Why do we sleep? What is the biological basis of dreaming? This course provides students with an overview of our current scientific understanding of sleep and dreaming. Class will consist of both lectures and discussions. In addition to a midterm and final, there will be two class projects, as well as a class presentation in which students can frame and answer their own question.


Important Dates

Feb. 4 — begin sleep log

Feb. 19 — end sleep log

Feb 22 — sleep log + analysis due

March 7 — Midterm based on lectures

March 14 — 1 page proposal due

April 7 — class presentations start

April 14 — mentation reports + analysis due

May 2 — last day of class


Texts

Required reading

Sleep by J. Allan Hobson, 1995. Scientific American Library, New York.

This book provides a good overview of many of the key ideas discussed in class, presented in an easy-to-read and well-illustrated manner.


Basics of Sleep Behavior

This syllabus provides a well-written overview of key topics in sleep, and is a good supplement to your textbook. This syllabus is also available on reserve in the Science Library.


Readings on reserve in Science Library

These readings include primary research articles and reviews, as well as excerpts from books and other popular articles. Some of these are available via ERes.



SCHEDULE READING



SLEEP BASICS


T Jan. 18 Course Administration
Survey
What is Sleep?

Ch. 1
Syl. A
F Jan. 21
Rhythms of Sleep I
Circadian RhythmS

Ch. 2
Syl. G
T Jan. 25
Rhythms of Sleep II
Polysomnography
REM/NREM


Syl. D
F Jan.28 Evolution of Sleep Ch. 3
Syl. B
T Feb.1 Sleep over the lifespan Ch. 4
Syl. C
F Feb.4
Sleep hygiene and sleep debt
Begin sleep log


Ch. 5
Syl. K
F Feb.8 Neuroanatomy of Sleep/Wake Ch. 6
Syl. E
T Feb.11 Neuromodulation Syl. F
T Feb.15 Dreaming I
Ch. 7
Syl. H
F Feb.18 Drugs and Sleep Syl. J
T Feb.22

Sleep Disorders
Sleep logs due (5%)


Ch. 8
Syl. L
F Feb.25 Functions of Sleep I Ch. 9
Syl. I



MIDTERM BREAK FEB 28 - MAR 3


T Mar.7 Midterm (20%) based on lectures







ADVANCED TOPICS IN SLEEP



F Mar.10
Sleep and Memory Consolidation I
guest lecture: Dr. Bob Stickgold



F Mar.14 Sleep and Memory Consolidation II
1 page proposal due (5%)

F Mar.17 Update on REM Sleep and Dreaming
T Mar.21 Lucid Dreams
F Mar.24
Weird States
-- sleep paralysis
-- night terrors


T Mar.28 Narcolepsy
F Mar.31
Drosophila Day
guest lecture: Dr. Ravi Allada



T Apr.4 Update on Human Sleep Research





CLASS PRESENTATIONS



F Apr.7 Class Presentations Begin (25%)
T Apr.11 Class Presentations
F Apr.14
Class Presentations
Mentation Report Analysis due (10%)



W Apr.19 Class Presentations
Nightcap hypnograms due (5%)
(Brandeis Friday)





Passover Apr.20-27
Study day Apr.28



T May 2 last day of class
discuss results of class project





Final Exam Period
--- Final (30%)

Instructor: Ken Leslie // Office hours by appointment or Thursdays 11am - noon
(kleslie@brandeis.edu) // Lab Phone: (781) 736-3182 // Room 201 Bassine, Nelson & Turrigiano Lab