Figure 3. Model for synaptic potentiation by NGF in neuron/myocyte
co-cultures.
NGF binds to TrkA receptors on the sympathetic neuron,
leading to an increase in the release of norepinephrine at the terminal
upon neuronal stimulation. Norepinephrine binds receptors on the cardiac
myocyte resulting in an increase in the rate of contraction.
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