Brandeis Home Page Brandeis Life Sciences Life Science Faculty Susan J. Birren

Figure 3. Model for synaptic potentiation by NGF in neuron/myocyte co-cultures.

NGF binds to TrkA receptors on the sympathetic neuron, leading to an increase in the release of norepinephrine at the terminal upon neuronal stimulation. Norepinephrine binds receptors on the cardiac myocyte resulting in an increase in the rate of contraction.

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