One
of the fundamental problems in neuroscience is understanding
how circuit function arises from the intrinsic properties
of individual neurons and their synaptic connections. Of
particular interest to us today is the extent to which similar
circuit outputs can be generated by multiple mechanisms,
both in different individual animals, or in the same animal
over its life-time. As an experimental preparation we exploit
the advantages of the central pattern generating circuits
in the crusctacean stomatogastric nervous system. Central
pattern generators are groups of neurons found in vertebrate
and invertebrate nervous systems responsible for the generation
of specific rhythmic behaviors such as walking, swimming,
and breathing. The central pattern generators in the stomatogastric
ganglion (STG) of lobsters and crabs are ideal for many
analyses because the STG has only about 30 large neurons,
the connectivity is established, the neurons are easy to
record from, and when the stomatogastric ganglion is removed
from the animal, it continues to produce rhythmic motor
patterns.
How
do neuromodulators and neuromodulatory neurons reconfigure
circuits so that the same group of neurons can produce
a variety of behaviorally relevant outputs?
- How can networks be both stable over the life-time of
the animal despite ongoing turnover of membrane proteins
such as channels and receptors? How is network stability
maintained over long time periods? To what extent do similar
network outputs result from different underlying mechanisms
or solutions?
To address these questions we employ electrophysiological,
biophysical, computational, anatomical, biochemical, and
molecular techniques.
Recent
Publications:
Swensen, A.M., Golowasch, J., Christie, A.E.,
Coleman, M.J., Nusbaum, M.P., and Marder, E. (2000) GABA
and GABA responses in the stomatogastric ganglion of the
crab, Cancer borealis. J. Exp. Biol., 203:
2075-2092. [abstract]
Richards, K.S. and Marder, E. (2000) The
actions of crustacean cardioactive peptide on adult and
developing stomatogastric ganglion motor patterns. J.
Neurobiol. 44: 31-44. [abstract]
Swensen, A.M. and Marder, E. (2000) Multiple
peptides converge to activate the same voltage-dependent
current in a central pattern generating circuit. J. Neurosci.
20: 6752-6759. [abstract]
Marder, E. (2000) Colored Chalk. Current
Biol., 10: R613. [pdf
file]
Marder, E. (2000) Models identify hidden assumptions.
Nature Neurosci. 3: 1198.
Marder, E. (2000) Motor pattern generation.
Curr. Opin. Neurobiol. 10: 691-698. [abstract]
Nusbaum, M.P., Blitz, D.M., Swensen, A.M.,
Wood, D., and Marder, E. (2001) The roles of co-transmission
in neural network modulation. TINS 24: 146-154.
[abstract]
Marder, E. (2001) Moving rhythms. Nature,
410: 755.
Soto-Treviņo, C., Thoroughman, K.A., Marder,
E., and Abbott, L.F. (2001) Activity-dependent modification
of inhibitory synapses in models of rhythmic neural networks.
Nature Neuroscience, 4: 297-303. [abstract]
Swensen, A.M. and Marder, E. (2001) Modulators
with convergent cellular actions elicit distinct circuit
outputs. J. Neuroscience, 21: 4050-4058. [abstract]
Goldman, M.S., Golowasch, J., Marder, E.,
and Abbott, L.F. (2001) Global structure, robustness, and
modulation of neuronal models. J. Neuroscience, 21:
5229-5238. [abstract]
Marder, E. and Bucher, D. (2001) Central pattern
generators and the control of rhythmic movements. Current
Biol., 11: R986-R996. [abstract]
Li, L., Pulver, S.R., Kelley, W.P., Thirumalai,
V., Sweedler, J.V., and Marder, E. (2002) Orcokinin peptides
in developing and adult crustacean stomatogastric nervous
systems and pericardial organs. J. Comp. Neurol.,
444:227-244.
Golowasch, J., Goldman, M., Abbott, L.F, and
Marder, E. (2002) Failure of averaging in the construction
of conductance-based neuron models. J. Neurophysiol.,
87: 11291131. [abstract]
Thirumalai, V. and Marder, E. (2002) Colocalized
neuropeptides activate a central pattern generator by acting
on different circuit targets. J. Neuroscience, 22:
18741882. [abstract]
Pulver, S.R. and Marder, E. (2002) Neuromodulatory
complement of the pericardial organ in the embryonic lobster,
Homarus americanus. J. Comp. Neurol., 451:
79-90.
Marder, E. (2002) Non-mammalian models for
studying neural development and function. Nature,
417: 318-321. [abstract]
Marder, E. and Thirumalai, V. (2002) Cellular,
synaptic, and network effects of neuromodulation. Neural
Networks, 15: 479-493. [abstract]
Marder, E. and Prinz, A.A. (2002) Modeling
stability in neuron and network function: the role of activity
in homeostasis. BioEssays, 24:1145-1154. [abstract]
Marder, E. and Prinz, A.A. (2003) Current
Compensation in neuronal homeostasis. Neuron, 37:
2-4. [abstract]
Abbott, L.F., Thoroughman, K., Prinz, A.,
Thirumalai, V. and Marder, E. (2003) Activity-dependent
modification of intrinsic and synaptic conductances in neurons
and rhythmic networks. In Van Ooyen, A., ed. Modeling Neural
Development (MIT Press, Cambridge MA).
Richards, K.S., Simon, D.J., Pulver, S.R.,
Beltz, B.S. and Marder, E. (2003) Serotonin in the developing
stomatogastric system of the lobster, Homarus americanus.
J. Neurobiol. 54: 380-392. [abstract]
Prinz, A.A., Thirumalai, V. and Marder, E.
(2003) The functional consequences of changes in the strength
and duration of synaptic inputs to oscillatory neurons.
J. Neurosci. 23: 943-954. [abstract]
Pulver, S.R., Thirumalai, V., Richards, K.S.
and Marder, E. (2003) Dopamine and histamine in the developing
stomatogastric system of the lobster, Homarus americanus.
J. Comp. Neurol 462: 400-414. [abstract]
Bucher, D., Thirumalai, V. and Marder, E.
(2003) Axonal dopamine receptors activate peripheral spike
initiation in a stomatogastric motor neuron. J. Neurosci.,
23: 6866-6875. [abstract]
Luther, JA, Robie AA, Yarotsky J, Reina C,
Marder E, and Golowasch J. (2003) Episodic Bouts of Activity
Accompany Recovery of Rhythmic Output By a Neuromodulator-
and Activity-Deprived Adult Neural Network. J. Neurophysiol.
90:2720-2730. [abstract]
[download
article]
Li, L., Kelley, W.P., Billimoria, C.P., Christie,
A.E., Pulver, S.R., Sweedler, J.V., and Marder, E. (2003)
Mass spectrometric investigation of the neuropeptide complement
and release in the pericardial organs of the crab, Cancer
borealis. J. Neurochem, 87: 642-656. [abstract]
Birmingham, J.T., Billimoria, C.P., DeKlotz,
T.R., Stewart, R.A. and Marder, E. (2003) Differential and
history dependent modulation of a stretch receptor in the
stomatogastric system of the crab, Cancer borealis.
J. Neurophysiol, 90: 3608 - 3616. [abstract]
Prinz, A.A., Billimoria, C.P, and Marder,
E. (2003) An alternative to hand-tuning conductance-based
models: construction and analysis of data bases of model
neurons. J. Neurophysiol., 90:3998-4015. [abstract]
[Download
Article]
Christie, A.E., Stein, W., Quinlan, J.E.,
Beenhakker, M., Marder, E., and Nusbaum, M.P. (2003) Actions
of a histaminergic/peptidergic projection neuron on rhythmic
motor patterns in the stomatogastric nervous system of the
crab, Cancer borealis. J. Comp. Neurol.,
469:153 - 169 [abstract]
Mahadevan A, Lappe J, Rhyne RT, Cruz-Bermudez
ND, Marder E, Goy MF. (2004) Nitric oxide inhibits the rate
and strength of cardiac contractions in the lobster Homarus
americanus by acting on the cardiac ganglion. J Neurosci.
24:2813-24. [abstract]
Prinz AA, Abbott LF, Marder E. (2004) The
dynamic clamp comes of age. Trends Neurosci. 27:218-24.
Goaillard JM, Schulz DJ, Kilman VL, Marder
E. (2004) Octopamine modulates the axons of modulatory projection
neurons. J Neurosci. 24(32):7063-73. [abstract]
Pulver SR, Bucher D, Simon DJ, Marder E. (2004)
Constant amplitude of postsynaptic responses for single
presynaptic action potentials but not bursting input during
growth of an identified neuromuscular junction in the lobster,
Homarus americanus. J Neurobiol. [Epub ahead of print]
[abstract]
Destexhe A, Marder E.(2004) Plasticity in
single neuron and circuit computations. Nature.
431:789-95. [abstract]
Prinz AA, Bucher D, Marder E. (2004) Similar
network activity from disparate circuit parameters. Nat
Neurosci. 7:1345-52. [abstract]
Bucher D, Prinz AA, Marder E. (2005) Animal-to-animal
variability in motor pattern production in adults and during
growth. J Neurosci. 25:1611-9. [abstract]
Marder E, Rehm KJ.(2005) Development of central
pattern generating circuits. Curr Opin Neurobiol.
15:86-93. [abstract]
Soto-Trevino C, Rabbah P, Marder E, Nadim
F. (2005) A computational model of electrically coupled,
intrinsically distinct pacemaker neurons. J Neurophysiol.
94:590-604. [abstract]
Marder E, Bucher D, Schulz DJ, Taylor AL.
(2005) Invertebrate central pattern generation moves along,
Curr Biol. 15:R685-99. [abstract]
Billimoria CP, Li L, Marder E. (2005) Profiling
of neuropeptides released at the stomatogastric ganglion
of the crab, Cancer borealis with mass spectrometry. J Neurochem.
95:191-9. [abstract]
Thirumalai V, Prinz AA, Johnson CD, Marder
E. (2006) Red pigment concentrating hormone strongly enhances
the strength of the feedback to the pyloric rhythm oscillator
but has little effect on pyloric rhythm period. J Neurophysiol.
95:1762-70. [abstract]
Schulz DJ, Goaillard JM, Marder E. (2006)
Variable channel expression in identified single and electrically
coupled neurons in different animals, Nat Neurosci.
9:356-62. [abstract]
Cruz-Bermudez ND, Fu Q, Kutz-Naber KK, Christie
AE, Li L, Marder E. (2006) Mass spectrometric characterization
and physiological actions of GAHKNYLRFamide, a novel FMRFamide-like
peptide from crabs of the genus Cancer. J Neurochem.
2006 May;97:784-99. [abstract]
Bucher D, Taylor AL, Marder E. (2006) Central
pattern generating neurons simultaneously express fast and
slow rhythmic activities in the stomatogastric ganglion.
J Neurophysiol. 2006 Jun;95:3617-32. [abstract]
Taylor AL, Hickey TJ, Prinz AA, Marder E. (2006) Structure
and visualization of high-dimensional conductance spaces.
J Neurophysiol. 2006 Aug;96:891-905. Epub 2006 May
10. [abstract]
Goaillard JM, Marder E. (2006) Dynamic clamp analyses of
cardiac, endocrine, and neural function. Physiology (Bethesda).
2006 Jun; 21:197-207. Review. [abstract]
Billimoria CP, DiCaprio RA, Birmingham JT, Abbott LF, Marder
E. (2006) Neuromodulation of spike-timing precision in sensory
neurons. J Neurosci. 2006 May 31; 26:5910-9. [abstract]
Marder E, Goaillard JM. (2006) Variability, compensation
and homeostasis in neuron and network function.Nat Rev Neurosci.
2006 Jul; 7:563-74. Review. [abstract]
Marder E, Bucher D. (2007) Understanding circuit dynamics
using the stomatogastric nervous system of lobsters and
crabs. Annu Rev Physiol. 2007; 69:291-316.
[abstract]
Bucher D, Johnson CD, Marder E. (2007) Neuronal morphology
and neuropil structure in the stomatogastric ganglion of
the lobster, Homarus americanus. J Comp Neurol. 2007
Mar 10; 501:185-205. [abstract]
Last update:
February 23, 2007. E-mail comments or questions to the webmaster.
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