eve marderEve Marder, Ph.D.
Professor of Biology
Member, US National Academy of Sciences & Institute of Medicate

Modulation of Neural Networks

Ph.D., University of California, San Diego

Contact Information

 One of the fundamental problems in neuroscience is understanding how circuit function arises from the intrinsic properties of individual neurons and their synaptic connections. Of particular interest to us today is the extent to which similar circuit outputs can be generated by multiple mechanisms, both in different individual animals, or in the same animal over its life-time. As an experimental preparation we exploit the advantages of the central pattern generating circuits in the crustacean stomatogastric nervous system. Central pattern generators are groups of neurons found in vertebrate and invertebrate nervous systems responsible for the generation of specific rhythmic behaviors such as walking, swimming, and breathing. The central pattern generators in the stomatogastric ganglion (STG) of lobsters and crabs are ideal for many analyses because the STG has only about 30 large neurons, the connectivity is established, the neurons are easy to record from, and when the stomatogastric ganglion is removed from the animal, it continues to produce rhythmic motor patterns.

ModulatorsWork in the lab centers on three main questions:

  1. How do neuromodulators and neuromodulatory neurons reconfigure circuits so that the same group of neurons can produce a variety of behaviorally relevant outputs?

  2. How can networks be both stable over the lifetime of the animal despite ongoing turnover of membrane proteins such as channels and receptors? How is network stability maintained over long time periods? To what extent do similar network outputs result from different underlying mechanisms or solutions?.

  3. How variable are the sets of parameters that govern circuit function across animals? How can animals with disparate sets of circuit parameters respond reliably to perturbations such as neuromodulators and temperature?

To address these questions we employ electrophysiological, biophysical, computational, anatomical, biochemical, and molecular techniques.

CrabNeuronRecent Publications:

Williams AH, Kwiatkowski MA, Mortimer AL, Marder E, Zeeman ML, Dickinson PS. Animal-to-animal variability in the phasing of the crustacean cardiac motor pattern: an experimental and computational analysis. J Neurophysiol. 2013;109(10):2451-65. [abstract] [full text in PubMed Central].

Williams AH, Calkins A, O'Leary T, Symonds R, Marder E, Dickinson PS. The neuromuscular transform of the lobster cardiac system explains the opposing effects of a neuromodulator on muscle output. J Neurosci. 2013;33(42):16565-75. [abstract] [full text in PubMed Central].

Rinberg A, Taylor AL, Marder E. The effects of temperature on the stability of a neuronal oscillator. Plos Comput Biol. 2013;9(1):e1002857. [abstract] [full text in PubMed Central].

O'Leary T, Williams AH, Caplan JS, Marder E. Correlations in ion channel expression emerge from homeostatic tuning rules. Proc Natl Acad Sci U S A. 2013;110(28):E2645-54. [abstract] [full text in PubMed Central].

Marder E. Grandmother elephants. eLife. 2013;2:e01140. [abstract] [full text in PubMed Central].

Marder E. Luck, jobs and learning. eLife. 2013;2:e00676. [abstract] [full text in PubMed Central].

Marder E. Crossing oceans. eLife. 2013;2:e00477. [abstract] [full text in PubMed Central].

Katz P, Grillner S, Wilson R, Borst A, Greenspan R, Buzsaki G, Martin K, Marder E, Kristan W, Friedrich R, Chklovskii D. Vertebrate versus invertebrate neural circuits. Curr Biol. 2013;23(12):R504-6. [abstract].

Gutierrez GJ, O'Leary T, Marder E. Multiple mechanisms switch an electrically coupled, synaptically inhibited neuron between competing rhythmic oscillators. Neuron. 2013;77(5):845-58. [abstract] [full text in PubMed Central].

Gutierrez GJ, Marder E. Rectifying electrical synapses can affect the influence of synaptic modulation on output pattern robustness. J Neurosci. 2013;33(32):13238-48. [abstract] [full text in PubMed Central].

Gerhard F, Kispersky T, Gutierrez GJ, Marder E, Kramer M, Eden U. Successful reconstruction of a physiological circuit with known connectivity from spiking activity alone. Plos Comput Biol. 2013;9(7):e1003138. [abstract] [full text in PubMed Central].

Bucher D, Marder E. SnapShot: Neuromodulation. Cell. 2013;155(2):482- e1. [abstract].

Birren SJ, Marder E. Neuroscience. Plasticity in the neurotransmitter repertoire. Science. 2013;340(6131):436-7. [abstract].

Bargmann CI, Marder E. From the connectome to brain function. Nat Methods. 2013;10(6):483-90. [abstract].

Tang LS, Taylor AL, Rinberg A, Marder E. Robustness of a rhythmic circuit to short- and long-term temperature changes. J Neurosci. 2012;32(29):10075-85. [abstract] [full text in PubMed Central].

Marder E. A good life. eLife. 2012;1:e00353. [abstract] [full text in PubMed Central].

Marder E. Neuromodulation of neuronal circuits: back to the future. Neuron. 2012;76(1):1-11. [abstract] [full text in PubMed Central].

Kispersky TJ, Caplan JS, Marder E. Increase in sodium conductance decreases firing rate and gain in model neurons. J Neurosci. 2012;32(32):10995-1004. [abstract] [full text in PubMed Central].

Callaway EM, Marder E. Common features of diverse circuits. Curr Opin Neurobiol. 2012;22(4):565-7. [abstract].

Brookings T, Grashow R, Marder E. Statistics of neuronal identification with open- and closed-loop measures of intrinsic excitability. Front Neural Circuits. 2012;6:19. [abstract] [full text in PubMed Central].

Szabo TM, Chen R, Goeritz ML, Maloney RT, Tang LS, Li L, Marder E. Distribution and physiological effects of B-type allatostatins (myoinhibitory peptides, MIPs) in the stomatogastric nervous system of the crab Cancer borealis. J Comp Neurol. 2011;519(13):2658-76. [abstract] [full text in PubMed Central].

Marder E, Taylor AL. Multiple models to capture the variability in biological neurons and networks. Nat Neurosci. 2011;14(2):133-8. [abstract] [full text in PubMed Central].

Marder E. Variability, compensation, and modulation in neurons and circuits. Proc Natl Acad Sci U S A. 2011;108 Suppl 3:15542-8. [abstract] [full text in PubMed Central].

Kispersky T, Gutierrez GJ, Marder E. Functional connectivity in a rhythmic inhibitory circuit using Granger causality. Neural Syst Circuits. 2011;1(1):9. [abstract] [full text in PubMed Central].

Tang LS, Goeritz ML, Caplan JS, Taylor AL, Fisek M, Marder E. Precise temperature compensation of phase in a rhythmic motor pattern. PLoS Biol. 2010;8(8). [abstract] [full text in PubMed Central].

Marder E, Tang LS. Coordinating different homeostatic processes. Neuron. 2010;66(2):161-3. [abstract] [full text in PubMed Central].

Marder E. Why so long? Curr Biol. 2010;20(10):R426. [abstract].

Grashow R, Brookings T, Marder E. Compensation for variable intrinsic neuronal excitability by circuit-synaptic interactions. J Neurosci. 2010;30(27):9145-56. [abstract] [full text in PubMed Central].

Goaillard JM, Taylor AL, Pulver SR, Marder E. Slow and persistent postinhibitory rebound acts as an intrinsic short-term memory mechanism. J Neurosci. 2010;30(13):4687-92. [abstract] [full text in PubMed Central].

Tobin AE, Cruz-Bermudez ND, Marder E, Schulz DJ. Correlations in ion channel mRNA in rhythmically active neurons. PLoS One. 2009;4(8):e6742. [abstract] [full text in PubMed Central].

Taylor AL, Goaillard JM, Marder E. How multiple conductances determine electrophysiological properties in a multicompartment model. J Neurosci. 2009;29(17):5573-86. [abstract] [full text in PubMed Central].

Marder E. Electrical synapses: rectification demystified. Curr Biol. 2009;19(1):R34-5. [abstract].

Ma M, Szabo TM, Jia C, Marder E, Li L. Mass spectrometric characterization and physiological actions of novel crustacean C-type allatostatins. Peptides. 2009;30(9):1660-8. [abstract] [full text in PubMed Central].

Grashow R, Brookings T, Marder E. Reliable neuromodulation from circuits with variable underlying structure. Proc Natl Acad Sci U S A. 2009;106(28):11742-6. [abstract] [full text in PubMed Central].

Goaillard JM, Taylor AL, Schulz DJ, Marder E. Functional consequences of animal-to-animal variation in circuit parameters. Nat Neurosci. 2009;12(11):1424-30. [abstract] [full text in PubMed Central].


Dr. Marder's publications at PubMed


Last reviewed: Oct 31, 2013. E-mail comments or questions to the webmaster.

 

 
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