Research focus: Our lab takes a multi-disciplinary approach to studying the cytoskeleton, a highly dynamic network of interconnected tubes and fibers found in all living cells (eukaryotic and prokaryotic). We are focused on actin filaments, one of the three principal systems of cytoskeletal fibers, and how their polymerization dynamics and spatial organization drives key cellular processes, such as endocytosis, intracellular transport, polarized cell growth and cytokinesis.
Specifically, we use genetics, biochemistry, cell imaging and structural techniques to dissect the functions of large biological machines that control actin cytoskeletal dynamics. These include protein complexes that nucleate actin filament assembly (Arp2/3 complex and formins) and promote rapid turnover of actin filaments (Srv2/CAP, cofilin, Aip1 and profilin).
We welcome any questions or reagent requests. Please e-mail us with any feedback or requests you might have.
E-mail: goode@brandeis.edu Please see our Members page for individual e-mail addresses.
Mailing address: Dr. Bruce Goode Rosenstiel Center MS 029 Brandeis University 415 South Street Waltham, MA 02454
Lab Phone: 781-736-2454
Fax: 781-736-2405
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