The goal of our research is to understand the molecular basis of actin cytoskeleton remodeling events in yeast and mammalian cells, and how functions of the actin and
microtubule cytoskeletons are coordinated. We take a multidisciplinary approach combining genetics, biochemistry, structural biology, single molecule analysis, and
live-cell imaging to obtain a quantitative view of the molecular mechanisms and dynamics involved.
actin filaments by TIRF microscopy
formin and actinin in isolated rat cardiac myocyte
actin, microtubules and DNA
in budding yeast cytokinesis
in budding yeast cytokinesis
direction of movement
GFP, actin and
microtubules in motile cells
microtubules in motile cells
bundled actin filaments by EM
6/3/2013
Big Contratulations to Sal on passing his Qualifying Exam!
5/28/2013
Welcome to incoming grad student Sean Guo, and summer REU students Sarah and Justin!
5/12/2013
Farewell and congratulations to our recent BS and MS grads: Jessica, Leslie, Leor, Jaclyn!
5/5/2013
Congrats to Leslie and Leor on successful defenses of their undergrad honors theses!
4/20/2013
Casey's paper on the mechanism of GMF's filament debranching is in press at Current Biology!
4/3/2013
Richa's paper on Drosophila APC/Formin collaboration accepted at JBC!
3/29/2013
Goodbye and Congratulations to Dennis Breitsprecher, moving on to his new job in Munich!
1/7/2013
Welcome to David, rotating PhD student from the MCB program. He will work with Brian.
12/21/2012
Ben Smith's paper on Arp2/3 complex single molecule analysis was accepted at PNAS!
12/18/2012
Dennis Breitsprecher gave talk on Srv2/CAP at the ASCB meeting (actin minisymposium).
12/03/2012
Welcome to Agnieszka Collins, new research scientist starting in the lab today!
11/15/2012
Tonight, 6pm at Tufts Med School: Julian is giving a talk on length control of actin networks.
11/07/2012
Welcome to Anna and Gönen, PhD students in the MCB program, starting their rotation with us!
Welcome to Anna and Gönen, PhD students in the MCB program, both starting their rotation with us!
10/08/2012
Six Goode lab members will present their work at ASCB meeting, including a Minisymposium talk!
Six Goode lab members will present their work at the ASCB annual meeting, including a Mini-symposium talk. Come see us in San Francisco this December!
09/10/2012
Leor Needleman, Brandeis senior undergraduate, joins the research team to work on Formins.
08/31/2012
We welcome Mariya and Sarah, first year PhD students, who are rotating in the Goode lab.
08/15/2012
Goodbye and Congratulations to Faisal Chaudhry, who starts his new job at Regeneron this month!
07/14/2012
Brian and Julian will present their work at the GRC in NH; Bruce will give talk on opening night.
Brian and Julian to present their work at the GRC (Plant and Microbial Cytoskeleton) in NH; Bruce will give talk on opening night.
05/28/2012
Dennis Breitsprecher's "rocket launcher" paper was accepted at Science for the June 1 issue!
Dennis Breitsprecher's "rocket launcher" paper on the mechanism of collaborative actin assembly between two actin nucleators is accepted at Science for the June 1 issue.
05/20/2012
Undergrad Steve Feldman has graduated with highest honors, and departed for Dentistry school.
05/17/2012
Sal Alioto (first year PhD student in MCB program) has joined the Goode lab - welcome Sal!
05/17/2012
Sankar Maiti (now at IISER in Kolkata) published in CSK on full-length mDia1 structure & activity.
05/16/2012
Adam Johnston passed his final qualifying exam, and looks forward to years of bench research.
05/14/2012
Annie Rankova graduated with her MS and has started as lab manager / research tech. Foolish girl!
10/28/2011
Casey's mini-review on actin branching/debranching published in CSK.
09/07/2011
Brian's paper defining Bud6 as a nucleation-promoting factor is out at MBoC.
08/16/2011
Melissa's paper on regulation of the formin Bnr1 by Smy1 is out at Developmental Cell.
07/29/2011
Kristin's last day as Goode lab tech. Good luck at Harvard!
07/08/2011
Sasha Bear got a haircut! Visit the lab to see her new 'do.
06/10/2011
We welcome REU students Veronika Kivenson and Long Le to the lab for the summer.
05/25/2011
Julian passed his Inside qualifying exam and was awarded an AHA fellowship on the same day!
05/18/2011
Congratulations to Adam on passing his Outside qualifying exam!
05/05/2011
Welcome to the Goode Lab's newest member: MCB grad student Adam Johnston.