Parasite/Antibiotic Drug Discovery

  Targeting prokaryotic enzymes in a eukaryotic parasite

 
 

Sun, Xin E.; Sharling, Lisa; Muthalagi, Mani; Mudeppa, Devaraja G.; Pankiewicz, Krzysztof W.; Felczak, Krzysztof; Rathod, Pradipsinh K.; Mead, Jan; Striepen, Boris and Hedstrom, Lizbeth.  Prodrug activation by Cryptosporidium thymidine kinase. J. Biol. Chem. 285, 15,916-15,922 (2010). [abstract]


Umejiego, Nwakaso N.;  Gollapalli, Deviprasad;  Sharling, Lisa; Volftsun, Anna; Lu, Jennifer; Benjamin, Nicole N.; Stroupe, Adam H.;  Riera1, Thomas V.; Striepen,, Boris; Hedstrom, Lizbeth.  Targeting a prokaryotic protein in a eukaryotic pathogen:  identification of lead compounds against Cryptosporidiosis. Chem. Biol. 15, 70-77 (2008). [abstract]

featured in Science Editor's Choice, Faculty of 1000, Voice of America, Science Daily and Cryptosporidium Blog.


Striepen, Boris; Pruijssers, Andrea J.P.;  Huang, Jingling; Li, Catherine;  Gubbels, Marc Jan;  Umejiego, Nwakaso N.; Hedstrom, Lizbeth & Kissinger, Jessica C.  Gene transfers in the evolution of parasite nucleotide biosynthesis.  Proc. Natl. Acad. Sci. USA 101, 3154-3159 (2004). [abstract]

 

Featured Publications

Together with the Striepen laboratory at the University of Georgia and the Mead laboratory at Emory University, we are mining the genome of Cryptosporidium to identify new drug targets.  Surprisingly, Cryptosporidium has obtained several genes via lateral transfer from bacteria;  the proteins encoded by these genes are highly diverged from their host counterparts, which should facilitate the development of specific inhibitors.


see also “IMPDH-targeted drugs for cryptosporodiosis” and “IMPDH as a target for antibiotic chemotherapy