1. Enzymes of natural product biosynthesis


Filamentous fungi produce a wide variety of natural products, including penicillin and mycophenolic acid.    Uffe Mortensen (DTU) and colleagues at the Danish Technical University have developed the genetic and analytical tools required to delineate these biosynthetic pathways.  We are characterizing the fascinating enzymes that emerge from this work.

Featured Publications

X. E. Sun, B.G. Hansen, and L. Hedstrom. Kinetically Controlled Drug Resistance: How Penicillium brevicompactum Survives Mycophenolic Acid. J. Biol. Chem., 40595-600 (2011). abstract

B.G. Hansen, X.E. Sun, H.J. Genee,C.S. Kaas, J.B. Nielsen,U.H. Mortensen, J.C. Frisvad, and L. Hedstrom. Adaptive evolution of drug targets in producer and non-producer organisms. Biochemical Journall 441, 219-26 (2011). abstract