Kadener Lab

Molecular Neurobiology and RNA Metabolism Laboratory

Publications

2018

Patop IL, Kadener S. “CircRNAs in Cancer” Current Opinion in Genetics & Development, 48:121-127 (2018) [Web]

2017

Buchumenski I, Bartok O, Ashwal-Fluss R, Pandey V, Porath HT, Levanon EY, Kadener S. “Dynamic hyper-editing underlies temperature adaptation in Drosophila.” Plos Genetics 10, 1371 (2017) [Web]

Levin-Klein R., Fraenkel S., Lichtenstein M., Matheson L., Bartok O., Nevo Y., Kadener S., Corcoran A., Cedar H., Bergman Y. “Clonally stable VK allelic choice instructs IgK repertoire”. Nature Comm. 8, 15575 (2017). [Web]

Pamudurti N., Bartok O., Jens O., Ashwal-Fluss R., Stottmeister C., Ruhe L., Hanan M., Wyler E., Perez-Hernandez D., Ramberger E., Shenzis S., Samson M., Dittmar G., Landthaler M., Chekulaeva M., Rajewsky N. and Kadener S. “Translation of circRNAs”. Molecular Cell 66(1), 9-21 (2017). [Web]

Afik S. 1, Bartok O. 1, Artyomov M., Shishkin A., Kadri S., Zhu X., Gutman M., Garber M.* and Kadener S.* “Defining the 5’ and 3’ landscape of the Drosophila transcriptome with ExoCAGE and RNaseH-seq”. Nucleic Acids Research 47(11): e95; 1-16 (2017). [Web]

2016

Cohen-Hadad Y., Altarescu G., Eldar-Geva T., Levi-Lahad E., Zhang M., Rogaeva, E. Gotkine M., Bartok O., Ashwal-Fluss R., Kadener S., Epsztejn-Litman S., Eiges R. “Marked differences in C9orf72 methylation status and isoform expression between C9/ALS human embryonic and induced pluripotent stem cells”. Stem Cell Reports 8(7), 927-940 (2016). [Web]

Mezan S., Feuz JD, Deplancke B. and Kadener S. “PDF signaling is an integral part of the Drosophila circadian molecular oscillator”. Cell Reports 17(3), 708-719 (2016). [Web]

Hanan M., Soreq H. and Kadener S. “CircRNAs in the brain”. RNA Biology Nov28:1-7 (2016).[Web]

Derr A, Yang C, Zilionis R, Sergushichev A, Blodgett DM, Redick S, Bortell R, Luban J, Harlan DM, Kadener S, Greiner DL, Klein A, Artyomov MN, Garber M. “End Sequence Analysis Toolkit (ESAT) expands the extractable information from single-cell RNA-seq data”. Genome Research 26(10), 1397-1410 (2016).[Web]

Chikne V.*, Doniger T.*, Bartok O.*, Eliaz D.*, Cohen Chalamish S., Tschudi C., Unger R., Hashem Y., Kadener S. and Michaeli S. “Pseudouridylation in Trypanosoma brucei rRNA is developmentally regulated in positions critical for ribosome function”. Scientific Reports 6, 25296:1-13 (2016).[Web]

2015

Tattikota SG., Rathjen T., Hausser J., Khedkar A., Kabra UD., Pandey V., Sury M., Wessels HH., Mollet IG., Eliasson L., Selbach M., Zinzen RP., Zavolan M., Kadener S, Tschöp MH, Jastroch M, Friedländer MR., Poy MN. “miR-184 regulates pancreatic β-Cell function according to glucose metabolism”. J. Biol. Chem. 290 (2015).[Web]

Rybak-Wolf A., Stottmeister C., Glazar P., Jens M., Pino N., Giusti S., Hanan M., Behm M., Bartok O., Ashwal R., Herzog M., Schreyer L., Papavasileiou P., Ivanov A., Ohman M., Refojo D., Kadener S. and Rajewsky N. “Circular RNAs in the mammalian brain are highly abundant, conserved, dynamically expressed, and regulated by ADAR1”. Molecular Cell 58 (2015).[Web]

Bartok O., Teesalu M., Pandey V., Hanan M., Poukkula M., Havula E., Moussaieff A., Vodala S., Nahmias Y., Kadener S.* and Hietakangas V.* “Cabut-dependent repressive branch of the sugar sensing transcriptional network regulates glyceroneogenesis”. * Corresponding authors. EMBO J. 34 (2015).[Web]

Lerner I.*, Bartok O.*, Afik S., Menet J., Wolfson V., Weissbein U., Haimovich D., Gafni C., Friedman N., Rosbash M. and Kadener S. “Clk post-transcriptional control denoises circadian transcription in time and space”. Nature Communications 6 (2015).[Web]

Stelzer Y., Bar S., Bartok O., Afik S., Ronen D., Kadener S.* and Benvenisty N.* “Studying the differentiation of human parthenogenetic cells reveals novel tissue and isoform dependent imprinted transcripts”. * Corresponding authors. Cell Reports 11(2):308 (2015).[Web]

2014

Ashwal-Fluss R., Meyer M., Pamudurti N.R., Ivanov A., Bartok O., Evantal N., Hanan M., Memczak S., Rajewsky N.* and Kadener S.* “CircRNA biogenesis and canonical splicing compete with each other” . Molecular Cell 55:172 (2014).[Web]

Weiss R., Bartok O., Mezan S., Malka Y and Kadener S. “Synergistic Interactions between the Molecular and Neuronal Circadian Networks Drive Behavioral Circadian Rhythms in Drosophila melanogaster”. PloS Genetics 10:e1004252 (2014).[Web]

2013

Mezan S., Ashwal-Fluss R., Shenhav R., Garber M. and Kadener S. “Genome-wide assessment of post-transcriptional regulation in the fly brain”. Frontiers in Molecular Neuroscience 6:49 (2013).[Web]

Bartok O., Kyriacou C., Levine J., Sehgal A. and Kadener S. “Adaptation of molecular circadian clockwork to environmental changes: a role for alternative splicing and miRNAs”. Proc R. Soc. B. 280:2013001 (2013).[Web]

Pandey V., Turm H., Bekenstein U., Shifman S. and Kadener S. “A new in vivo model of pantothenate kinase-associated neurodegeneration reveals a surprising role for transcriptional regulation in PKAN pathogenesis”. Frontiers in Cell Neuroscience 7: 146 (2013).[Web]

Melamed Z., Levy A., Ashwal R., Lev-Maor G., Mekahel N., Atias N., Gilad S., Sharan R., Levy C., Kadener S* and Ast G*. “Alternative splicing regulates biogenesis of miRNAs located across exon-intron junctions”. * Corresponding authors. Mol. Cell 50:869 (2013).[Web]

2012

Belacortu Y., Weiss R., Kadener S. and Paricio N. “Transcriptional activity and nuclear localization of Cabut, the Drosophila ortholog of vertebrate TGF-β-inducible early-response gene (TIEG) proteins”. PLoS One 7(2):e32004 (2012).[Web]

2011

Belancortu Y., Weiss R., Kadener S. and Paricio N. “Expression of Drosophila cabut during early embryogenesis, dorsal closure and nervous system development”. Gene Expr Patterns 3-4: 190 (2011).[Web]

Bekenstein U. and Kadener S. “What can Drosophila teach us about iron-accumulation neurodegenerative disorders?” J. Neural Trans 118(3):389 (2011).[Web]

2010

Van der Linden A.M., Beverly M., Kadener S., Rodriguez J., Wasserman S., Rosbash M. and Sengupta P. “Genome-Wide Analysis of Light and Temperature-Entrained Circadian Transcripts in C. elegans”. PLoS Biology 8(10):e10000503 (2010).[Web]

2009

Fathallah-Shaykh H.M., Bona J.L. and Kadener S. “Mathematical Model of the Drosophila Circadian Clock: Loop Regulation and Transcriptional Integration”. Biophys J. 97(9): 2399 (2009). Cover article. Selected for Faculty of 1000 (Factor 8 Must read)[Web]

Kadener S., Menet J., Sugino K., Horwich M.D., Weissbein U., Nawathean P., Vagin V., Zamore P., Nelson S. and Rosbash M. “A role for miRNAs in the Drosophila circadian clock”. Genes Dev. 23(8):2179 (2009).[Web]

Kadener S., Rodriguez J., Abruzzi K. and Rosbash M. “Genome-wide identification of targets of the drosha-pasha/DGCR8 complex”. RNA 15(4): 537 (2009). [Web]

2008

Kadener S., Schoer R., Menet J. and Rosbash M. “Circadian transcription contributes to core period determination in Drosophila”. PLOS Biology 6(5): 119 (2008). [Web]