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Post-Doctoral Researcher


Education
2017 - PhD Biochemistry, Brandeis University, Waltham, USA
2010 - Dual B.S. in Biotechnology and Chemistry. City University of New York New York, NY USA

Contact
Email: cwilson @ brandeis.edu
Office: Volen 443
Dept. of Biochemistry, MS 009
Brandeis University
415 South Street
Waltham, MA 02454, USA
Phone (Lab): (781) 736-2326

Christopher Wilson


Research Interests

Life has produced molecular machines with breath-taking efficiency, enzymes are capable of accelerating chemical reactions by 10^5 to 10^17 times far out performing the best man-made catalysts. Currently we do not understand how life accomplished this momentous engineering feat. My interest is in combining proven biophysical and biochemical techniques with "molecular paleontology" and directed evolution methods to learn from life how it constructed molecular machines. It is my hope that a better understanding of how life evolved enzymes to be such fantastic machines will lead to significant improvements in designing enzymes with novel reactions.


Publications

Vy Nguyen*, Christopher Wilson*, Marc Hoemberger, John B. Stiller, Roman Agafonov, Steffen Kutter, Justin English, Douglas Theobald, Dorothee Kern Evolutionary drivers of thermoadaptation in enzyme catalysis. Science (2017) 355(6322):289-294

Agafonov R.V., Wilson C, Kern D. Evolution and intelligent design in drug development. Frontiers in Molecular Biosciences (2015) 2:27

Wilson C, Agafonov RV, Hoemberger M, Kutter S, Zorba A, Halpin J, Buosi V, Otten R, Waterman D, Theobald DL, Kern D. Using ancient protein kinases to unravel a modern cancer drug's mechanism. Science (2015) 347(6224):882-

Agafonov R.V., Wilson C, Otten R, Buosi V, Kern D. Energetic dissection of Gleevec's selectivity toward human tyrosine kinases. Nature Structural & Molecular Biology (2014) 21(10):848-53

Wilson C., Ramai R., Serjanov D., Lama N., Levinger L., and Chang E. A Flexible Arm and Tether in the Long Form of tRNase Z Characterized by Limited Proteolysis and Mass Spectrometry PlosOne (2013) 8(7): 66942

Levinger L., Hopkinson A., Desetty R., and Wilson C. Effect of changes in the flexible arm on tRNase Z processing kinetics J. Biol. Chem (2009) 284: 15685-15691