PhD Candidate in Biochemistry
2014 - B.A.Chemistry - Biochemistry @ Western Connecticut State University, Danbury, CT
Email: pfinneran @ brandeis.edu
Dept. of Biochemistry, MS 009
415 South Street
Waltham, MA 02454, USA
Phone (Lab): (781) 736-2326
Thirty-two non-receptor tyrosine kinases have been identified in humans. All of these kinases had evolved from the same common ancestor at one point in time. These proteins are similar by their same function, but they differ in the mechanism in which they are regulated and by their substrates. I am interested in researching the mechanism of how a kinase is able to recognize its target protein. By using ancestral sequence reconstruction (ASR) it may be possible to map what evolutionary changes in the protein led to a difference in its specificity. I also research how regulatory abilities evolved over time using similar techniques.