Bacterial cGAS-like enzymes synthesize diverse nucleotide signals.
Whiteley AT, Eaglesham JB, de Oliveira Mann CC, Morehouse BR, Lowey B, Nieminen EA, Danilchanka O, King DS, Lee ASY, Mekalanos JJ*, Kranzusch PJ*. (*Co-corresponding)
Nature. Online 2019 Feb 20. [Web]


eIF3d is an mRNA cap-binding protein required for specialized translation initiation.
Lee ASY, Kranzusch PJ, Doudna JA, Cate JH.
. 2016 Aug 4; 10.1038/nature18954. [Web]


Ancient Origin of cGAS-STING reveals mechanism of universal 2’, 3’ cGAMP signaling.
Kranzusch PJ*, Wilson SC*, Lee ASY, Berger JM, Doudna JA, Vance RE. (*Co-first)
Molecular Cell. 2015 Sept 17; 59(6): 891-903. [Web]

eIF3 targets cell proliferation mRNAs for translational activation or repression.
Lee ASY, Kranzusch PJ, Cate JH.
Nature. 2015 Jun 04; 522:111-114. [Web]

Integrase-mediated spacer acquisition during CRISPR–Cas adaptive immunity.
Nuñez JK, Lee ASY, Engelman A, Doudna JA.
Nature. 2015 Mar 12; 519:193-198. [Web]


Structure-Guided Reprogramming of Human cGAS Dinucleotide Linkage Specificity.
Kranzusch PJ, Lee ASY, Wilson SC, Solovykh MS, Vance RE, Berger JM, Doudna JA.
Cell. 2014 Aug 28; 158(5):1011-1021. [Web]

Host factors required for vesicular stomatitis virus infection.
Lee ASY, Burdeinick-Kerr R, Whelan S.P.
Journal of Virology. 2014 Aug 1; 88(15): 8355-8360. [Web]


Structure of human cGAS reveals a conserved family of second-messenger enzymes in innate immunity.
Kranzusch PJ, Lee ASY, Berger JM, Doudna JA.
Cell Reports. 2013 May 23; 3(5): 1362-1368. [Web]

A ribosome-specialized translation initiation pathway is required for cap-dependent translation of vesicular stomatitis virus mRNAs.
Lee ASY, Burdeinick-Kerr R, Whelan S.P.
Proc Natl Acad Sci USA. 2013 Jan 2; 110(1): 324-9. 2007-2012 [Web]


Construction and manipulation of a new Kaposi’s sarcoma-associated herpesvirus bacterial artificial chromosome clone.
Brulois K, Chang H, Lee ASY, Ensser A, Wong LY, Toth Z, Lee SH, Lee HR, Myoung J, Ganem DE, Oh TK, Kim JF, Gao SG, Jung JU.
Journal of Virology. 2012 Sept; 86(18): 9708-9720.

Peroxisomes are signaling platforms for antiviral innate immunity.
Dixit E, Boulant S, Zhang Y, Lee ASY, Odendall C, Shum B, Hacohen N, Chen ZJ, Whelan SP, Fransen M, Nibert ML, Superti-Furga G, Kagan JC.
Cell. 2010 May 14;141(4):668-81.

Helicobacter hepaticus urease is not required for intestinal colonization but promotes hepatic inflammation in male A/JCr mice.
Ge Z, Lee A, Whary MT, Rogers AB, Maurer KJ, Taylor NS, Schauer DB, Fox JG.
Microbial Pathogenesis. 2008 Jul; 45(1): 18-24.

Receptor Determinants of Zoonotic Transmission of New World Hemorrhagic Fever Arenaviruses.
Radioshitzky S, Kuhn J, Spiropoulous C, Albarino C, Nguyen D, Salazar-Bravo J, Dorfman T, Lee AS, Wang E, Ross S, Choe H, Farzan M.
Proc Natl Acad Sci USA. 2008 Feb 19;105(7):2664-9.

Bacterial cytolethal distending toxin promotes the development of dysplasia in a model of microbially induced hepatocarcinogenesis.
Ge Z, Rogers AB, Feng Y, Lee A, Xu S, Taylor NS, Fox JG.
Cell Microbiology. 2007 Aug; 9(8): 2070-2080.

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