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The hippocampal-VTA loop

How novelty detection in the hippocampus activates the dopamine system, thereby activating late LTP and gating the flow of information into long-term memory.

  1. Storage, recall, and novelty detection of sequences by the hippocampus: elaborating on the SOCRATIC model to account for normal and aberrant effects of dopamine. Lisman JE, Otmakhova NA. Hippocampus. 2001; 11(5): 551-68. PDF format ]

  2. The hippocampal-VTA loop: controlling the entry of information into long-term memory. Lisman JE, Grace AA. Neuron, 2005 June 2; 46(5): 703-13. [ PDF format ]




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