NMDAR-based Neural Integrator
An important test of the model has to do with the effects of different
single neuron perturbations during integration. First, neurons are
not intrinsically bistable such that depolarizing a neuron cannot turn
it on and should leave integraton unaffected. Second, hyperpolarization
should only be able to turn off a neuron temporarily and leave integrator function intact. These simulations are shown below.
The "off condition" is the same as shown on Figure 7c of the paper. Note, that
if the transients effects do not have time to decay away then the
response of the network to subsequent inputs is somewhat different. Graphically
you can see this from the non overlap of the red and black pyramids.
Furthermore, figure B shows that when a neuron is in its bistable range
(neurons 7-12) during the hyperpolarization, then (and only then!) it can be reset.
Questions? Please contact Adam (kepecs@brandeis.edu) or Sridhar (sraghava@brandeis.edu).