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Memory storage by CaMKII:

 

CaMKII as molecular switch with the stability, reversibility and structural involvement necessary to store synaptic memory

  1. A mechanism for memory storage insensitive to molecular turnover: a bistable autophosphorylating kinase. Proc Natl Acad Sci USA. 1985 May; 82(9):3055-7. [ PDF ]

  2. A model of synaptic memory: a CaMKII/PP1 switch that potentiates transmission by organizing an AMPA receptor anchoring assembly. Lisman JE, Zhabotinsky AM. Neuron. 2001 Aug 2;31(2):191-201. [ PDF ]

  3. The molecular basis of CaMKII function in synaptic and behavioural memory. Lisman J, Schulman H, Cline H. Nat Rev Neurosci. 2002 Mar;3(3):175-90. [ PDF ]

  4. The stability of a stochastic CaMKII switch: dependence on the number of enzyme molecules and protein turnover. Miller P, Zhabotinsky AM, Lisman JE, Wang XJ. PLoS Biol. 2005 Apr;3(4):e107. Epub 2005 Mar 29. [ PDF ]

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