neuron properties

This folder contains 7 files that characterize all database neurons by giving their maximal membrane conductances, spontaneous activity type, spontaneous spike or burst frequency or resting potential, number of voltage maxima per burst, burst duration, phase response properties, activity type under current step injection, number of voltage maxima per burst during DC current injection, and more.

File "conductancelevels.dat":

This file defines the maximal conductances of each neuron in the database. It has 9 columns and 1,679,616 lines. The columns are:

1) Model neuron number.
2) Conductance level for INa. Multiplied by 100 mS/cm2, this number gives the maximal conductance density of INa in this neuron.
3) Conductance level for ICaT. Multiplied by 2.5 mS/cm2, this number gives the maximal conductance density of ICaT in this neuron.
4) Conductance level for ICaS. Multiplied by 2 mS/cm2, this number gives the maximal conductance density of ICaS in this neuron.
5) Conductance level for IA. Multiplied by 10 mS/cm2, this number gives the maximal conductance density of IA in this neuron.
6) Conductance level for IKCa. Multiplied by 5 mS/cm2, this number gives the maximal conductance density of IKCa in this neuron.
7) Conductance level for IKd. Multiplied by 25 mS/cm2, this number gives the maximal conductance density of IKd in this neuron.
8) Conductance level for IH. Multiplied by 0.01 mS/cm2, this number gives the maximal conductance density of IH in this neuron.
9) Conductance level for Ileak. Multiplied by 0.01 mS/cm2, this number gives the maximal conductance density of Ileak in this neuron.

The conductance level file is often useful, but in a sense redundant, because the conductance levels can be directly calculated from the model neuron number. The conductance levels are the digits of (model neuron number - 1) in base 6, in the same order as the columns in the conductance level file. For example, to get the conductance levels of model neuron number 134,283, the decimal integer 134,282 has to be converted to base 6. The result is 2513402. This means that the conductance levels for model neuron number 134,283 are: 0 for INa, 2 for ICaT, 5 for ICaS, 1 for IA, 3 for IKCa, 4 for IKd, 0 for IH, 2 for Ileak.

File "spontaneous type periodorpotential minmaxnumber.dat":

This file contains the classification results for the steady state spontaneous activity of all neurons. It has 4 columns and 1,679,616 lines. The columns are:

1) Model neuron number.
2) Integer number indicating the spontaneous activity type. 0 means silent, 1 means spiking, 2 means bursting, 3 means irregular.
3) For silent cells: resting potential in V. For spikers: spike period in s. For bursters: burst period in s. For irregular cells: average inter-maximum-interval in s.
4) Number of voltage minima and maxima stored in the corresponding minmax file for this neuron (see below).

File "spontaneous burstduration maxperburst.dat":

This file contains information about all bursters. It has 3 columns and 1,120,235 lines. The columns are:

1) Model neuron number.
2) Number of voltage maxima per burst for the regular bursters. An entry of 3333 in this column indicates that the model neuron is an irregular burster.
3) Burst duration (= burst period - largest inter-maximum-interval) in s. For irregular bursters, the entry is 0.

File "PRC.dat":

This file contains phase response curves (PRCs) for all regular bursters. The PRCs were simulated with a conductance pulse of 1,000 nS amplitude that lasted for 25% of the intrinsic burst period of the burster and had a reversal potential of -80 mV. The conductance pulse was delivered at phase increments of 0.1, starting at phase 0, which was assigned to the first voltage maximum in the burst.
The file has 12 columns and 1,065,225 lines. The columns are:

1) Model neuron number.
2) Burst period in s.
3) Phase response to a conductance pulse starting at phase 0.0.
4) Phase response to a conductance pulse starting at phase 0.1.
5) Phase response to a conductance pulse starting at phase 0.2.
6) Phase response to a conductance pulse starting at phase 0.3.
7) Phase response to a conductance pulse starting at phase 0.4.
8) Phase response to a conductance pulse starting at phase 0.5.
9) Phase response to a conductance pulse starting at phase 0.6.
10) Phase response to a conductance pulse starting at phase 0.7.
11) Phase response to a conductance pulse starting at phase 0.8.
12) Phase response to a conductance pulse starting at phase 0.9.

File "injection types frequencies minmaxnumbers.dat":

This file contains information about the response of each model neuron to injection of DC current steps from 0 nA to 3 nA and from 0 nA to 6 nA. It has 12 columns and 1,679,616 lines. The columns are:

1) Model neuron number.
2) Integer number indicating the spontaneous activity type. 0 means silent, 1 means spiking, 2 means bursting, 3 means irregular.
3) Integer number indicating the steady state activity type during 3 nA current injection. 0 means silent, 1 means tonically active, 2 means bursting, 3 means irregular.
4) Integer number indicating the steady state activity type during 6 nA current injection. 0 means silent, 1 means tonically active, 2 means bursting, 3 means irregular.
5) Spontaneous frequency of voltage maxima in Hz.
6) Steady state maxima frequency during 3 nA current injection in Hz.
7) Steady state maxima frequency during 6 nA current injection in Hz.
8) Number of voltage maxima during the first second after the injection current was stepped from 0 nA to 3 nA.
9) Number of voltage maxima during the first second after the injection current was stepped from 0 nA to 6 nA.
10) Number of spontaneous voltage maxima and minima stored in the corresponding injminmax file for this neuron (see below).
11) Number of voltage maxima and minima during 3 nA current injection stored in the corresponding injminmax file for this neuron.
12) Number of voltage maxima and minima during 6 nA current injection stored in the corresponding injminmax file for this neuron.

File "injection 3nA maxperburst.dat":

This file contains the number of voltage maxima per burst for all neurons that show steady state bursting during 3 nA current injection. It has 2 columns and 710,667 lines. The columns are:

1) Model neuron number.
2) Number of voltage maxima per burst for the neurons that show regular bursting during 3 nA current injection. An entry of 3333 in this column indicates that the model neuron is an irregular burster during 3 nA current injection.

File "injection 6nA maxperburst.dat":

This file contains the number of voltage maxima per burst for all neurons that show steady state bursting during 6 nA current injection. It has 2 columns and 554,915 lines. The columns are:

1) Model neuron number.
2) Number of voltage maxima per burst for the neurons that show regular bursting during 6 nA current injection. An entry of 3333 in this column indicates that the model neuron is an irregular burster during 6 nA current injection.