| Thu 5/23/19 4 pm | Abelson 229 |
| MRSEC Seminar |
| Nathan Derr (Smith College) |
| Investigating cytoskeletal motor mechanisms and (bio)physical force integration using DNA origami |
Cytoplasmic dynein and kinesin-1 are opposite polarity microtubule-based motor proteins that contribute to essential aspects of eukaryotic cell biology, including mitosis and intracellular cargo transport. In vivo studies indicate that these motors often team-up in small ensembles to achieve their diverse tasks. Yet, how the myriad biochemical and biophysical properties of individual motors, and their cargos, contribute to the emergent motile properties of ensemble transport remains elusive. To investigate these aspects of multiple-motor driven cargo transport, we employ the molecular construction techniques of DNA origami to create well-defined systems of motor ensembles on customizable cargos. This approach enables us to both control and investigate how individual aspects of the motors and their cargo affect the ensemble's motility. Our work focuses on how cargo shape, size, and rigidity interact with motor type and copy number to determine overall motility. Our research trajectory has led us recently to design 1) spherical DNA origami structures for investigating the role of cargo geometry in ensemble transport, and 2) modular DNA origami structures for studying the (bio)physics of nano-scale force integration among teams of dynein motors. |
| Hosted by John Berezney |
|
| Tue 5/28/19 2 pm | Gerstenzang 124 |
| Thesis Seminar (Graduate Program in Molecular and Cell Biology) |
| Danielle DiTirro (Sengupta Lab) |
| C. elegans Tubby dynamically modulates olfactory cilia membrane morphogenesis and phosphoinositide composition |
|
| Fri 5/31/19 12:30 pm | Gerstenzang 124 |
| Special Seminar |
| Aryn Gittis (Department of Biological Sciences and Center for the Neural Basis of Cognition, Carnegie Mellon University) |
| Cell-Specific Neuromodulation For Long-Lasting Motor Effects In A Mouse Model of Parkinson's Disease |
| Hosted by Leslie Griffith |
|
| Thu 6/6/19 4 pm | Abelson 229 |
| MRSEC Seminar |
| Ethan Levien (Postdoc - Brandeis/Harvard) |
| TBA |
| Hosted by John Berezney |
|
| Thu 6/20/19 4 pm | Abelson 333 |
| MRSEC Seminar |
| Tim Fessenden (MIT Biology) |
| TBA |
| Hosted by John Berezney |
|
| Fri 6/21/19 12:30 pm | Gerstenzang 124 |
| Brandeis Postdoctoral Seminar Series |
| Kimberly Rizzolo (Pandelia Lab) |
| Denis Patterson (Touboul Lab) |
| Hosted by Brandeis Postdoc Association |
|
| Fri 6/28/19 12:30 pm | Gerstenzang 124 |
| Brandeis Postdoctoral Seminar Series |
| Erin Clark (Nelson Lab) |
| Elena Sapede (Haber Lab) |
| Hosted by Brandeis Postdoc Association |
|
Science at Brandeis