Seminars

Upcoming Seminars / Seminars This Week

Thu 8/17/17 12 noonGerstenzang 124
Career Development Seminar
Shantanu Jadhav Amy Lee Anna Moore Timothy Street Casey Wade (Brandeis University)
Academic Career Panel: How to transition from PhD to Post-Doc to PI

Mon 8/21/17 4 pmAbelson 229
MRSEC Seminar
Zhibin Guan (University of California, Irvine)
TBA

Wed 8/30/17 12 noonRosenstiel 118
Neurobiology Journal Club
Michael O'Donnell (Sengupta Lab)
TBA
Justin Shin (Jadhav Lab)
TBA

Tue 9/5/17 12:30 pmTBA
Joint Biology/Neuroscience Colloquium
Nevan Krogan (UCSF)
Using Systems Approaches for Studying Disease
Hosted by Jim Haber

Tue 9/5/17 4 pmAbelson 131
Physics Department Colloquium
Margaret Johnson (The Johns Hopkins University)
Protein self-assembly in the cell: Spatial and temporal control through membrane localization
Abstract: Cell division, endocytosis, and viral budding would not function without the localization and assembly of protein complexes on membranes. What is poorly appreciated, however, is that by localizing to membranes, proteins search in a reduced space that effectively drives up concentration. We have derived an accurate and practical analytical theory to quantify the significance of this dimensionality reduction in regulating protein assembly on membranes. We define a simple metric, an effective equilibrium constant, that allows for quantitative comparison of protein-protein interactions with and without membrane present. We find that many of the protein-protein interactions between pairs of proteins involved in clathrin-mediated endocytosis in human and yeast cells can experience enormous increases in effective protein-protein affinity (10-1000 fold) due to membrane localization. By developing new methods for reaction-diffusion simulation of protein structures, we further characterize the non-equilibrium dynamics of these assembly processes, with reaction parameters defined from experiment. Both theory and simulations highlight the power of membrane localization in triggering robust protein-protein binding, suggesting that it can play an important role in controlling the timing of endocytic protein coat formation.

Speaker Bio: Margaret Johnson joined the Biophysics faculty at Johns Hopkins University in 2013. She received her B.S. in Applied Math from Columbia University and her PhD in BioEngineering from UC Berkeley. She completed postdoctoral training in the Laboratory of Chemical Physics at the National Institutes of Health in Bethesda, MD. Her research focuses on understanding how the individual interactions between thousands of diverse components in the cell generate order and collective function at the right time and the right place. She develops theoretical and computational approaches to study the evolution and mechanics of dynamic systems of interacting and assembling proteins.

In 2011 she received an NIH Pathway to Independence Award (K99/R00) and in 2017 was named a Scialog Fellow by the Research Corporation for Scientific Advancement.

Hosted by Michael Hagan

Wed 9/6/17 12 noonRosenstiel 118
Neurobiology Journal Club
Hanoch Kaphzan (University of Haifa)
TBA
Hosted by Avi Rodal

Thu 9/7/17 4 pmAbelson 229
MRSEC Seminar
Jason Haaga (Lehigh University)
TBA

Tue 9/12/17 3:30 pmTBA
Chemistry Department Colloquium
Yimon Aye (Cornell)
Translating the Precision Electrophile Signaling Code
Hosted by Bing Xu

Tue 9/12/17 4 pmAbelson 131
Physics Department Colloquium
Michael Hagan (Brandeis)
TBA
Hosted by Bulbul Chakraborty, Bjoern Penning

Wed 9/13/17 12 noonRosenstiel 118
Neurobiology Journal Club
Chelsea Groves Kuhnle (Turrigiano/Van Hooser Labs)
TBA
Stephen Alkins (Griffith)
TBA

Fri 9/15/17 11:15 amTBD
Biochemistry-Biophysics Friday Lunchtime Pizza Talks
Chitta Das (Purdue University)
Manipulation of host ubiquitin signal by bacterial effectors
Hosted by Liz Hedstrom

Mon 9/18/17 4 pmGerstenzang 121
Chemistry Department Colloquium
Athanassios Panagiotopoulos (Princeton)
Free energies, solubilities, and nucleation rates of aqueous electrolyte solutions
Hosted by Judith Herzfeld

Tue 9/19/17 4 pmAbelson 131
Physics Department Colloquium
Daniel Whiteson & Jorge Cham (Fermilab)
TBA

Wed 9/20/17 12 noonRosenstiel 118
Neurobiology Journal Club
Mark Zielinski (Jadhav Lab)
TBA
Alexis Johns (Wingfield Lab)
TBA

Tue 9/26/17 4 pmAbelson 131
Physics Department Colloquium
Dapeng Bi (Northeastern University)
Mechanics of Epithelial Tissues: Structure, Rigidity and Fluidity
Hosted by Bulbul Chakraborty

Wed 9/27/17 12 noonRosenstiel 118
Neurobiology Journal Club
Joseph Wachutka (Katz Lab)
TBA
Lauren Tereshko (Sengupta Lab)
TBA

 
415 South Street, Waltham, MA 02453 (781) 736-2000