| Thu 8/17/17 12 noon | Gerstenzang 124 |
| Career Development Seminar |
| Shantanu Jadhav Amy Lee Anna Moore Timothy Street Casey Wade (Brandeis University) |
| Academic Career Panel: How to transition from PhD to Post-Doc to PI |
|
| Mon 8/21/17 4 pm | Abelson 229 |
| MRSEC Seminar |
| Zhibin Guan (University of California, Irvine) |
| TBA |
|
| Wed 8/30/17 12 noon | Rosenstiel 118 |
| Neurobiology Journal Club |
| Michael O'Donnell (Sengupta Lab) |
| TBA |
| Justin Shin (Jadhav Lab) |
| TBA |
|
| Tue 9/5/17 12:30 pm | TBA |
| Joint Biology/Neuroscience Colloquium |
| Nevan Krogan (UCSF) |
| Using Systems Approaches for Studying Disease |
| Hosted by Jim Haber |
|
| Tue 9/5/17 4 pm | Abelson 131 |
| Physics Department Colloquium |
| Margaret Johnson (The Johns Hopkins University) |
| Protein self-assembly in the cell: Spatial and temporal control through membrane localization |
Abstract: Cell division, endocytosis, and viral budding would not function without the localization and assembly of protein complexes on membranes. What is poorly appreciated, however, is that by localizing to membranes, proteins search in a reduced space that effectively drives up concentration. We have derived an accurate and practical analytical theory to quantify the significance of this dimensionality reduction in regulating protein assembly on membranes. We define a simple metric, an effective equilibrium constant, that allows for quantitative comparison of protein-protein interactions with and without membrane present. We find that many of the protein-protein interactions between pairs of proteins involved in clathrin-mediated endocytosis in human and yeast cells can experience enormous increases in effective protein-protein affinity (10-1000 fold) due to membrane localization. By developing new methods for reaction-diffusion simulation of protein structures, we further characterize the non-equilibrium dynamics of these assembly processes, with reaction parameters defined from experiment. Both theory and simulations highlight the power of membrane localization in triggering robust protein-protein binding, suggesting that it can play an important role in controlling the timing of endocytic protein coat formation. Speaker Bio: Margaret Johnson joined the Biophysics faculty at Johns Hopkins University in 2013. She received her B.S. in Applied Math from Columbia University and her PhD in BioEngineering from UC Berkeley. She completed postdoctoral training in the Laboratory of Chemical Physics at the National Institutes of Health in Bethesda, MD. Her research focuses on understanding how the individual interactions between thousands of diverse components in the cell generate order and collective function at the right time and the right place. She develops theoretical and computational approaches to study the evolution and mechanics of dynamic systems of interacting and assembling proteins. In 2011 she received an NIH Pathway to Independence Award (K99/R00) and in 2017 was named a Scialog Fellow by the Research Corporation for Scientific Advancement. |
| Hosted by Michael Hagan |
|
| Wed 9/6/17 12 noon | Rosenstiel 118 |
| Neurobiology Journal Club |
| Hanoch Kaphzan (University of Haifa) |
| TBA |
| Hosted by Avi Rodal |
|
| Thu 9/7/17 4 pm | Abelson 229 |
| MRSEC Seminar |
| Jason Haaga (Lehigh University) |
| TBA |
|
| Tue 9/12/17 3:30 pm | TBA |
| Chemistry Department Colloquium |
| Yimon Aye (Cornell) |
| Translating the Precision Electrophile Signaling Code |
| Hosted by Bing Xu |
|
| Tue 9/12/17 4 pm | Abelson 131 |
| Physics Department Colloquium |
| Michael Hagan (Brandeis) |
| TBA |
| Hosted by Bulbul Chakraborty, Bjoern Penning |
|
| Wed 9/13/17 12 noon | Rosenstiel 118 |
| Neurobiology Journal Club |
| Chelsea Groves Kuhnle (Turrigiano/Van Hooser Labs) |
| TBA |
| Stephen Alkins (Griffith) |
| TBA |
|
| Fri 9/15/17 11:15 am | TBD |
| Biochemistry-Biophysics Friday Lunchtime Pizza Talks |
| Chitta Das (Purdue University) |
| Manipulation of host ubiquitin signal by bacterial effectors |
| Hosted by Liz Hedstrom |
|
| Mon 9/18/17 4 pm | Gerstenzang 121 |
| Chemistry Department Colloquium |
| Athanassios Panagiotopoulos (Princeton) |
| Free energies, solubilities, and nucleation rates of aqueous electrolyte solutions |
| Hosted by Judith Herzfeld |
|
| Tue 9/19/17 4 pm | Abelson 131 |
| Physics Department Colloquium |
| Daniel Whiteson & Jorge Cham (Fermilab) |
| TBA |
|
| Wed 9/20/17 12 noon | Rosenstiel 118 |
| Neurobiology Journal Club |
| Mark Zielinski (Jadhav Lab) |
| TBA |
| Alexis Johns (Wingfield Lab) |
| TBA |
|
| Tue 9/26/17 4 pm | Abelson 131 |
| Physics Department Colloquium |
| Dapeng Bi (Northeastern University) |
| Mechanics of Epithelial Tissues: Structure, Rigidity and Fluidity |
| Hosted by Bulbul Chakraborty |
|
| Wed 9/27/17 12 noon | Rosenstiel 118 |
| Neurobiology Journal Club |
| Joseph Wachutka (Katz Lab) |
| TBA |
| Lauren Tereshko (Sengupta Lab) |
| TBA |
|
Science at Brandeis