Seminars

Upcoming Seminars / Seminars This Week

Thu 7/7/16 10 amAbelson 333
Thesis Seminar
Cong Qiao (Physics Department)
Simulations of curved assemblies in soft matter and biological systems

Thu 7/7/16 11 amAbelson 229
Brandeis Summer Institute (IGERT Summer Conference)
Daniel Goldstein (Brandeis)
A Kinetic Model of Active Extensile Bundles
Hosted by Prof. Albion Lawrence

Thu 7/7/16 12 noonRosenstiel 118
Brandeis Postdoctoral Summer Seminar Series ( )
Belinda Barbagallo (Brandeis University)
Neural circuit control of physiological homeostasis
Pizza Served
Hosted by Brandeis University Postdoctoral Association

Thu 7/7/16 2 pmShapiro Science Center 1-03 Library
MRSEC IRG 1
Huaimin Wang (Xu Lab)
Enzyme-Regulated Supramolecular Assemblies of Cholesterol Conjugates against Drug-Resistant Ovarian Cancer Cells
Here we present phosphotyrosine cholesterol conjugates for selectively killing cancer cells, including platinum-resistant ovarian cancer cells. Remarkably, the tyrosine-cholesterol conjugates exhibits higher potency and higher selectivity than cisplatin against drug resistant human ovarian carcinoma cell lines (e.g., A2780cis) in cell assay. The conjugate increases the degree of non-covalent oligomerization upon enzymatic dephosphorylation in aqueous buffer. This enzymatic conversion of cholesterol conjugates also results in the assemblies of the cholesterol conjugates inside and outside cells and leads to cell death. Moreover, preliminary mechanistic study suggests that the formed assemblies of the conjugates not only interact with actin filaments and microtubules, but also affect lipid rafts. As the first report of multifaceted supramolecular assemblies of cholesterol conjugate against cancer cell, this work illustrates the integration of enzyme catalysis and self-assembly of essential biological small molecules on and inside cancer cells as a promising strategy for developing multifunctional therapeutics to treat drug-resistant cancers.

References:

1. Gao, Y.; Shi, J. F.; Yuan, D.; Xu, B*."Imaging enzyme-triggered self-assembly of small molecules inside live cells" Nat. Commun. 2012, 3, 1033.

2. Kuang, Y.; Shi, J. F.; Li, J.; Yuan, D.; Alberti, K. A.; Xu, Q. B.; Xu, B.* "Pericellular Hydrogel/Nanonets Inhibit Cancer Cells" Angew. Chem. Intl. Ed., 2014,53, 8104-8107.

3. Zhou, J.; Du, X. W.; Li, J.; Yamagata, N.; Xu, B.* "Taurine Boosts Cellular Uptake of Small D-peptides for Enzyme-Instructed Intracellular Molecular Self-assembly", J. Am. Chem. Soc. 2015, 137, 10040-10043.


Thu 7/7/16 3:30 pmShapiro Science Center GL14
Hiatt Summer Science Career Series
Jon Schlesinger (Hiatt Career Center)
Linked-in/Networking workshop

Fri 7/8/16 10 amAbelson 229
Brandeis Summer Institute (IGERT Summer Conference)
Julian Butcher (Brandeis University)
A Continuum Theory of Active Nematics in a Bounded, Two Dimensional System
Hosted by Prof. Albion Lawrence

Fri 7/8/16 11:30 amAbelson 229
Brandeis Summer Institute (IGERT Summer Conference)
Sumantra Sarkar (MIT)
Force Tiling: Finding patterns in the forces

Mon 7/11/16 10 amAbelson 229
Brandeis Summer Institute (IGERT Summer Conference)
Geoffrey Conklin (Brandeis University)
Chemical Modelling with Semi-Classical Valence Electrons
Hosted by Prof. Albion Lawrence

Mon 7/11/16 11:30 amAbelson 229
Brandeis Summer Institute (IGERT Summer Conference)
Paul Miller (Brandeis)
From the Ising model to cognition: exploring attractor states in neuroscience
Hosted by Prof. Albion Lawrence

Tue 7/12/16 10 amAbelson 229
Brandeis Summer Institute (IGERT Summer Conference)
Benjamin Hancock (Brandeis)
Statistical Mechanics and Hydrodynamics of Self-Propelled Hard Spheres
Hosted by Prof. Albion Lawrence

Tue 7/12/16 11:30 amAbelson 229
Brandeis Summer Institute (IGERT Summer Conference)
Biji Wong (Brandeis)
TBA
Hosted by Prof. Albion Lawrence

Thu 7/14/16 12 noonRosenstiel 118
Brandeis Postdoctoral Summer Seminar Series ( )
TBD
TBD
Pizza Served
Hosted by Brandeis University Postdoctoral Association

Thu 7/14/16 3:30 pmAbelson 333
Hiatt Summer Science Career Series
Jane Pavese (Hiatt Career Center)
Incorporating Summer Research into Your STEM resumes

Mon 7/18/16 1 pmShapiro Science Center 1-03 Library
MRSEC IRG 2
TBA
TBA

Thu 7/21/16 12 noonRosenstiel 118
Brandeis Postdoctoral Summer Seminar Series ( )
TBD
TBD
Pizza Served
Hosted by Brandeis University Postdoctoral Assocation

Thu 7/28/16 12 noonRosenstiel 118
Brandeis Postdoctoral Summer Seminar Series ( )
TBD
TBD
Pizza Served
Hosted by Brandeis University Postdoctoral Association

Wed 8/3/16 12 noonRosenstiel 118
Brandeis Postdoctoral Summer Seminar Series ( )
TBD
TBD
reschedule to Wed to avoid SciFest conflict; Pizza Served
Hosted by Brandeis University Postdoctoral Association

Thu 8/4/16 1 pmShapiro Science Center Atrium
Poster Session
Science Undergraduates
SciFest VI
Posters will display undergraduate research from across the Division of Science, including summer visitors and Brandeis students.
Hosted by The Division of Science

Thu 8/11/16 12 noonRosenstiel 118
Brandeis Postdoctoral Summer Seminar Series ( )
TBD
TBD
Pizza Served
Hosted by Brandeis University Postdoctoral Association

 
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