Nicastro Laboratory


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Our laboratory is studying the three-dimensional structure of macromolecular 

machines, organelles and cells using cryo-electron tomography.

We are focusing on the structure and function relationships of macromolecular

complexes in situ, i.e. in their native environment.

Areas of interest include the structure of eukaryotic flagella and the molecular

motor dynein, the cytoskeleton and bacteria, as well as the development of

Dymek et al. (2011) MBoC

cryo-EM and image processing techniques.