lab location:

Shapiro Science Center 1-08
(781)736-3176/3177
Interactive Map

shipping address:

Paradis Lab
Department of Biology
Kalman Receiving
Brandeis University
415 South St.
Waltham, MA 02454

Amy Ghiretti

Name: Amy Ghiretti

Position: Ph.D. Student

Education: B.S., Biology, College of William and Mary, 2008

Contact: aeghir@brandeis.edu

Hometown: New Providence, NJ

Personal Interests: I'm a big fan of television, movies, and entertainment news in general. If you have a random question about a TV show or movie, I'm probably the person to ask. I'm also one of many in the lab who is Harry Potter obsessed! In my spare time, I also enjoy horseback riding.

If I weren't a scientist I'd be... a writer for Entertainment Weekly.

Research Interests: My project involves the activity-regulated GTPase Rem2 and its role in neurodevelopmental processes. Using an RNAi-based approach, I have identified roles for Rem2 in synapse development, dendritic spine development, and the formation of the dendritic arborization. I am currently working to characterize the molecular signaling pathways through which Rem2 might be mediating its effects in neurons, and exploring the idea that Rem2 may be a key component of the mechanism by which neurons are able to respond to extracellular stimuli with the appropriate structural and functional changes.

Publications:

Ghiretti AE & Paradis S. (2011) The GTPase Rem2 regulates synapse development and dendritic morphology. Dev Neurobiol 71(5): 374-89.

Ghiretti AE & Paradis S. (2011) "The GTPase Rem2 regulates synapse development and dendritic morphology." Dev Neurobiol 71(5): 374-389.

Ghiretti AE, Kenny K, Marr MT 2nd, & Paradis S. (2013) "CaMKII-dependent phosphorylation of the GTPase Rem2 is required to restrict dendritic complexity." J Neurosci 33(15): 6504-15.

Moore AR, Ghiretti AE, & Paradis S. (2013) "A loss-of-function analysis reveals that endogenous Rem2 promotes functional glutamatergic synapse formation and restricts dendritic complexity." PLoS One 8(8).

Ghiretti AE, Moore AR, Brenner RG, Chen LF, West AE, Lau NC, Van Hooser SD, & Paradis S. (2014) "Rem2 is an activity-dependent negative regulator of dendritic complexity in vivo." J Neurosci 34(2): 392-407.