lab location:

Shapiro Science Center 1-08
Interactive Map

shipping address:

Paradis Lab
Department of Biology
Lab Supplies & Receiving – Kalman
Brandeis University
415 South St.
Waltham, MA 02454

Recent Publications

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Royer L, Shangraw K, Herzog JJ, Pouvreau S, Marr MT 2nd, Paradis S. The Metastasis Suppressor Protein Nme1 Is a Concentration-Dependent Modulator of Ca2+/Calmodulin-Dependent Protein Kinase II. Biochemistry. 2019 Jun 18;58(24):2710-2714. doi: 10.1021/acs.biochem.9b00121

Acker D, Paradis S, Miller P. Stable memory and computation in randomly rewiring neural networks. J Neurophysiol. 2019 Jul 1;122(1):66-80. doi: 10.1152/jn.00534.2018.

Royer, L., Herzog, J.J., Kenny, K., Tzvetkova, B., Cochrane, J. C., Marr, M.T. 2nd*, Paradis, S*. 2018. The Ras-like GTPase Rem2 is a potent inhibitor of calcium/calmodulin-dependent kinase II activity. J Biol Chem. In press. * co-corresponding authors 

McDermott, J.E., Goldblatt, D., Paradis, S. 2018. Class 4 Semaphorins and Plexin-B receptors regulate GABAergic and glutamatergic synapse development in the mammalian hippocampus. Mol. Cell Neurosci. 92: 50-66.

Moore, A.R., Richards, S.E., Kenny, K., Royer, L., Chan, U., Flavahan, K., Van Hooser, S.D.*, Paradis, S.* 2018. Rem2 stabilizes intrinsic excitability and spontaneous firing in visual circuit. eLife DOI: 10.7554/eLife.33092. * co-corresponding authors

Acker, D.W.M., Wong, I., Kang, M., Paradis, S. 2018. Semaphorin 4D promotes inhibitory synapse formation and suppresses seizures in vivo. Epilepsia doi: 10.1111/epi.14429.

Kenny, K., Royer, L., Moore, A.R., Chen, X., Marr, M.T. 2nd, Paradis, S. 2017. Rem2 signaling affects neuronal structure and function in part by regulation of gene expression. Mol. Cell Neurosci. 85: 190-201. PMCID: PMC5781234

Herzog J.*, Deshpande M.*, Shapiro, L., Rodal A.A., Paradis S. TDP-43 misexpression causes defects in dendritic growth. 2017. Sci Rep. 7: 15656. PMCID: PMC5688077 *authors contributed equally

Steinmetz CC, Tatavarty V, Sugino K, Shima Y, Joseph A, Lin H, Rutlin M, Lambo M, Hempel CM, Okaty BW, Paradis S, Nelson SB, Turrigiano GG. 2016. Upregulation of μ3A Drives Homeostatic Plasticity by Rerouting AMPAR into the Recycling Endosomal Pathway. Cell Rep. 16:2711-22.

Ghiretti AE, Paradis S. 2014. Molecular mechanisms of activity-dependent changes in dendritic morphology: role of RGK proteins. Trends Neurosci. 37:399-407.

Raissi AJ, Scangarello FA, Hulce KR, Pontrello JK, Paradis S. 2014. Enhanced potency of the metalloprotease inhibitor TAPI-2 by multivalent display. Bioorg Med Chem Lett. 24:2002-7.

Ghiretti, A.E., Moore, A.R., Brenner, R.G., Chen, L.-F., West, A.E., Lau, N.C., Van Hooser, S.D., and Paradis, S. 2014. Rem2 is an activity-dependent negative regulator of dendritic complexity in vivo. J Neurosci. 34: 392-407.

Raissi, A.J., Staudenmaier, E.K., David, S., Hu, L., Paradis, S. 2013. Sema4D localizes to synapses and regulates GABAergic synapse development as a membrane-bound molecule in the mammalian hippocampus. Mol. Cell Neurosci. 57: 23-32.

Moore, A.R., Ghiretti, A.E., and Paradis, S. 2013. A loss-of-function analysis reveals that endogenous Rem2 promotes functional glutamatergic synapse formation and restricts dendritic complexity. PLOS One 8: e74751.

Zeng, M., Kuzirian, M.S., Harper, L., Paradis, S., Nakayam, T., Lau, N. 2013. Organic small hairpin RNAs (OshR): a Do-It-Yourself platform for transgene-based gene silencing. Methods 63: 101-9.

Kuzirian, M.S., Moore, A. R., Staudenmaier, E., Friedel, R.H., and Paradis, S. 2013. The class 4 Semaphorin Sema4D promotes the rapid assembly of GABAergic synapses in rodent hippocampus. J Neurosci. 33: 8961-73.
- Commentary in Epilepsy Professional September 2013
- Highlighted in Science Business Exchange June 20, 2013

Ghiretti, A.E., Kenny, K., Marr, M.T.2nd and Paradis, S. 2013. CaMKII-dependent phosphorylation of the GTPase Rem2 is required to restrict dendritic complexity J Neurosci. 33: 6504-15.

Kuzirian, M.S., and Paradis, S. 2011. Distinct and Overlapping Mechanisms of Glutamatergic and GABAergic Synapse Formation. Prog. Neurobiol., 95: 68-87. [invited review]

Ghiretti, A.E. and Paradis, S. 2011. The GTPase Rem2 regulates synapse development and dendritic morphology. Dev Neurobiol. 71: 374-89.

Paradis, S. 2009. Pathfinding Molecules Branch Out: Semaphorin Family Members Regulate Synapse Development. In Hortsch, M. and Umemori, H. (Eds.), The Sticky Synapse: Cell Adhesion Molecules and Their Role in Synapse Formation and Maintenance (pp. 321-332). New York: Springer. [invited book chapter]

Paradis, S.*, Harrar, D.B.*, Lin, Y., Koon, A.C., Hauser, J.L., Griffith, E.C., Zhu, L., Brass, L.F., Chen, C., Greenberg, M.E. 2007. An RNAi-based Approach Identifies New Molecules Required for Glutamatergic and GABAergic Synapse Development. Neuron 53: 217-232.
*authors contributed equally

Flavell, S.W., Cowan, C.W., Kim, T.K., Greer, P.L., Lin, Y., Paradis, S., Griffith, E.C., Hu, L.S., Chen, C., Greenberg, M.E. 2006. Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse number. Science 311: 1008-1012.

Tolias, K.F., Bikoff, J.B., Burette, A., Paradis, S., Harrar, D., Tavazoie, S., Weinberg, R.J., Greenberg, M.E. 2005. The Rac1-GEF Tiam1 Couples the NMDA Receptor to the Activity-Dependent Development of Dendritic Arbors and Spines. Neuron 45: 525-538.

Paradis, S., Sweeney, S.T., Davis, G.W. 2001. Homeostatic Control of Presynaptic Release is Triggered by Postsynaptic Membrane Depolarization. Neuron 30: 737-749

Davis, G.W., Eaton, B., Paradis, S. 2001. Synapse Formation Revisited. Nat. Neurosci. 4: 558-560.

Paradis, S., Ailion, M., Toker, A., Thomas, J. H., Ruvkun, G. 1999. A PDK1 Homolog is Necessary and Sufficient to Transduce AGE-1 PI3 kinase Signals that Regulate Diapause in C. elegans. Genes & Development 13: 1438-1452.

Paradis, S. and Ruvkun, G. 1998. Caenorhabditis elegans Akt/PKB Transduces Insulin Receptor-like Signals from AGE-1 PI3 kinase to the DAF-16 Transcription Factor. Genes & Development 12: 2488-2498.

Ogg, S., Paradis, S., Gottlieb, S., Patterson, G.I., Lee, L., Tissenbaum, H.A., Ruvkun, G. 1997. The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature 389: 994-999.