Brandeis Professors Michael Rosbash, Jeff Hall (Emeritus) and Michael Young from Rockefeller University awarded the Nobel Prize. Congratulations!

RSS Recent Publications

  • Neural connectivity molecules best identify the heterogeneous clock and dopaminergic cell types in the <em>Drosophila</em> adult brain
    Our recent single-cell sequencing of most adult Drosophila circadian neurons indicated notable and unexpected heterogeneity. To address whether other populations are similar, we sequenced a large subset of adult brain dopaminergic neurons. Their gene expression heterogeneity is similar to that of clock neurons, i.e., both populations have two to three cells per neuron group. There […]
  • Dopamine and GPCR-mediated modulation of DN1 clock neurons gates the circadian timing of sleep
    The metronome-like circadian regulation of sleep timing must still adapt to an uncertain environment. Recent studies in Drosophila indicate that neuromodulation not only plays a key role in clock neuron synchronization but also affects interactions between the clock network and brain sleep centers. We show here that the targets of neuromodulators, G Protein Coupled Receptors […]
  • Recurrent circadian circuitry regulates central brain activity to maintain sleep
    Animal brains have discrete circadian neurons, but little is known about how they are coordinated to influence and maintain sleep. Here, through a systematic optogenetic screening, we identified a subtype of uncharacterized circadian DN3 neurons that is strongly sleep promoting in Drosophila. These anterior-projecting DN3s (APDN3s) receive signals from DN1 circadian neurons and then output […]
  • Transposable element landscapes in aging Drosophila
    Genetic mechanisms that repress transposable elements (TEs) in young animals decline during aging, as reflected by increased TE expression in aged animals. Does increased TE expression during aging lead to more genomic TE copies in older animals? To address this question, we quantified TE Landscapes (TLs) via whole genome sequencing of young and aged Drosophila […]
  • Loop-Mediated Isothermal Amplification Detection of SARS-CoV-2 and Myriad Other Applications
    As the second year of the COVID-19 pandemic begins, it remains clear that a massive increase in the ability to test for SARS-CoV-2 infections in a myriad of settings is critical to controlling the pandemic and to preparing for future outbreaks. The current gold standard for molecular diagnostics is the polymerase chain reaction (PCR), but […]
  • Development of a Saliva-Optimized RT-LAMP Assay for SARS-CoV-2
    Conventional reverse transcription quantitative polymerase chain reaction (RT-qPCR) technology has struggled to fulfill the unprecedented need for diagnostic testing created by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Complexity and cost hinder access to testing, and long turnaround time decreases its utility. To ameliorate these issues, we focus on saliva and introduce several […]

RSS Lab News

  • First Rosbash-Abovich Award Recipients Announced
    Michael Rosbash, the Peter Gruber Endowed Chair in Neuroscience and Professor of Biology and his wife, Nadja Abovich, established the Rosbash-Abovich Award as a way to inspire and acknowledge excellence in research by post-doctoral fellows and graduate students in the Brandeis life sciences. The Rosbash-Abovich award will be awarded annually. The award honors the most […]
  • Clocks, fruit flies, and Sweden
    We mentioned previously that Rosbash, Hall and Young are getting the Nobel Prize in Physiology or Medicine this year “for their discoveries of molecular mechanisms controlling the circadian rhythm”. The Physiology/Medicine lectures were on Thursday Dec 7 at 1 pm CET (7 am Brandeis time) and are still available to view. The Biology Department enjoyed watching […]
  • Rosbash, Hall & Young Awarded Nobel Prize
    Brandeis researchers Michael Rosbash, the Peter Gruber Endowed Chair in Neuroscience, and Professor Emeritus of Biology Jeffrey C. Hall have received this year’s Nobel Prize in Physiology or Medicine, together with Michael Young from The Rockefeller University,  for their pioneering work on the molecular mechanisms controlling circadian rhythm. The Guardian Nobel Press Release 2017 Nobel […]
  • The 7th Annual SPROUT Awards Are Available
    Post written by Fern Shamis. The 7th Annual SPROUT Awards are back and want to help you bring your research and entrepreneurial ambitions to life! Have a great idea? Does your research have the ability to impact the world? Need funding support to make your innovation a reality? Consider applying for a SPROUT award. In […]
  • Neurons that make flies sleep
    Sleep is known to be regulated by both intrinsic (what time is it?) and environmental factors (is it hot today?). How exactly these factors are integrated at the cellular level is a hot topic for investigation, given the prevalence of sleep disorders. Researchers in the Rosbash and Griffith labs are pursuing the question in the […]