Brandeis Professors Michael Rosbash, Jeff Hall (Emeritus) and Michael Young from Rockefeller University awarded the Nobel Prize. Congratulations!

RSS Recent Publications

  • Targeted RNA editing: novel tools to study post-transcriptional regulation
    RNA binding proteins (RBPs) regulate nearly all post-transcriptional processes within cells. To fully understand RBP function, it is essential to identify their in vivo targets. Standard techniques for profiling RBP targets, such as crosslinking immunoprecipitation (CLIP) and its variants, are limited or suboptimal in some situations, e.g. when compatible antibodies are not available and when […]
  • Protocol for using TRIBE to study RNA-protein interactions and nuclear organization in mammalian cells
    Targets of RNA-binding proteins discovered by editing (TRIBE) determines RNA-proteins interactions and nuclear organization with minimal false positives. We detail necessary steps for performing mammalian cell RBP-TRIBE to determine the targets of RNA-binding proteins and MS2-TRIBE to determine RNA-RNA interactions within the nucleus. Necessary steps for performing a TRIBE experiment are detailed, starting with plasmid/cell […]
  • Comment on "Circadian rhythms in the absence of the clock gene <em>Bmal1</em>"
    Ray et al (Reports, 14 February 2020, p. 800) recently claimed temperature-compensated, free-running mRNA oscillations in Bmal1 ^(-/-) liver slices and skin fibroblasts. We reanalyzed these data and found far fewer reproducible mRNA oscillations in this genotype. We also note errors and potentially inappropriate analyses.
  • Circadian Rhythms and the Transcriptional Feedback Loop (Nobel Lecture)*
    Circadian rhythms are present in most if not all animals, plants, and even photosynthetic cyanobacteria. These cyanobacterial clocks as well as plant clocks are very different from those of animals, with no credible homology between the different clock proteins. Therefore circadian rhythms probably emerged multiple times in evolution, which underscores their importance.
  • Internal state configures olfactory behavior and early sensory processing in <em>Drosophila</em> larvae
    Animals exhibit different behavioral responses to the same sensory cue depending on their internal state at a given moment. How and where in the brain are sensory inputs combined with state information to select an appropriate behavior? Here, we investigate how food deprivation affects olfactory behavior in Drosophila larvae. We find that certain odors repel […]
  • A transcriptomic taxonomy of <em>Drosophila</em> circadian neurons around the clock
    Many different functions are regulated by circadian rhythms, including those orchestrated by discrete clock neurons within animal brains. To comprehensively characterize and assign cell identity to the 75 pairs of Drosophila circadian neurons, we optimized a single-cell RNA sequencing method and assayed clock neuron gene expression at different times of day. The data identify at […]

RSS Lab News

  • First Rosbash-Abovich Award Recipients Announced
    Michael Rosbash, the Peter Gruber Endowed Chair in Neuroscience and Professor of Biology and his wife, Nadja Abovich, established the Rosbash-Abovich Award as a way to inspire and acknowledge excellence in research by post-doctoral fellows and graduate students in the Brandeis life sciences. The Rosbash-Abovich award will be awarded annually. The award honors the most […]
  • Clocks, fruit flies, and Sweden
    We mentioned previously that Rosbash, Hall and Young are getting the Nobel Prize in Physiology or Medicine this year “for their discoveries of molecular mechanisms controlling the circadian rhythm”. The Physiology/Medicine lectures were on Thursday Dec 7 at 1 pm CET (7 am Brandeis time) and are still available to view. The Biology Department enjoyed watching […]
  • Rosbash, Hall & Young Awarded Nobel Prize
    Brandeis researchers Michael Rosbash, the Peter Gruber Endowed Chair in Neuroscience, and Professor Emeritus of Biology Jeffrey C. Hall have received this year’s Nobel Prize in Physiology or Medicine, together with Michael Young from The Rockefeller University,  for their pioneering work on the molecular mechanisms controlling circadian rhythm. The Guardian Nobel Press Release 2017 Nobel […]
  • The 7th Annual SPROUT Awards Are Available
    Post written by Fern Shamis. The 7th Annual SPROUT Awards are back and want to help you bring your research and entrepreneurial ambitions to life! Have a great idea? Does your research have the ability to impact the world? Need funding support to make your innovation a reality? Consider applying for a SPROUT award. In […]
  • Neurons that make flies sleep
    Sleep is known to be regulated by both intrinsic (what time is it?) and environmental factors (is it hot today?). How exactly these factors are integrated at the cellular level is a hot topic for investigation, given the prevalence of sleep disorders. Researchers in the Rosbash and Griffith labs are pursuing the question in the […]