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Publications from 2007 (to top)
Clockwork Orange is a transcriptional repressor and a new Drosophila circadian pacemaker component. Kadener, S., Stoleru, D., McDonald, M., Nawathean, P., and Rosbash, M. Genes Dev 21:1675-1686 (2007).

A small conserved domain of Drosophila PERIOD is important for circadian phosphorylation, nuclear localization and transcriptional repressor activity. Nawathean, P., Stoleru, D., and Rosbash, M. MCB 27:5002-5013 (2007).

Per-Tim interactions with the photoreceptor cryptochrome mediate circadian temperature responses in Drosophila. Kaushik, R., Nawathean, P., Busza, A., Murad, A., Emery, P., and Rosbash, M. PLOS Biology 5:e146 (2007).

The Drosophila circadian neuronal network is a seasonal timer. Stoleru, D., Nawathean, P., de la Paz Fernandez, M., Menet, J.S., Fernanda Ceriani, M., and Rosbash, M. Cell 27:207-219 (2007).

A novel plasmid based microarray screen identifies suppressors of rrp6{delta} in Saccharomyces cerevisiae. Abruzzi, K., Denome, S., Olsen, J.R., Assenholt, J., Haaning, L.L., Jensen, T.H., and Rosbash, M. MCB 27:1044-1055 (2007).

Publications from 2006 (to top)

A genome wide analysis indicates that yeast pre-mRNA splicing is predominantly post-transcriptional. Tardiff, D.F., Lacadie, S.A. and Rosbash, M. Mol Cell 24:917-929 (2006).

Post-transcriptional mRNP tethers GAL genes to the nuclear periphery. Abruzzi, K.C., Belostotsky, D.A., Chekanova, J.A., Dower, K., and Rosbash, M. EMBO J. 25:4253-4262 (2006).

Neurotoxic protein expression reveals connections between the circadian clock and mating behavior in Drosophila. Kadener, S., Villella, A., Kula, E., Palm, K., Pyza, E., Botas, J., Hall, J.C., and Rosbash, M. PNAS 103:13537-13542 (2006).

In vivo commitment to yeast cotranscriptional splicing is sensitive to transcriptional elongation mutants. Lacadie, S.A., Tardiff, D.F., Kadener, S., and Rosbash, M. Genes Dev. 20:2055-2066 (2006).

Arrested yeast splicing complexes indicate stepwise snRNP recruitment during in vivo spliceosome assembly. Tardiff, D.F., and Rosbash, M. RNA 12:968-979 (2006).

PDF cycling in the dorsal protocerebrum of the Drosophila brain is not necessary for circadian clock function. Kula, E., Levitan, E.S., Pyza, E., and Rosbash, M. J. Biol. Rhythms 21:104-117 (2006).

Publications from 2005 (to top)

A resetting signal between Drosophila pacemakers synchronizes morning and evening activity. Stoleru, D., Peng, Y., Nawathean, P., and Rosbash, M. Nature 438:238-242 (2005).

Co-transcriptional spliceosome assembly dynamics and the role of U1 snRNA:5’ss base pairing in yeast. Lacadie, S.A. and Rosbash, M. Mol Cell, Mol Cell 19:65-75 (2005).

PERIOD1-associated proteins modulate the negative limb of the mammalian circadian clock. Brown, S.A., Ripperger, J., Kadener, S., Fleury-Olela, F. Vilbois, F., Rosbash, M., and Schibler, U. Science 308:693-6 (2005).

Assaying the Drosophila negative feedback loop with RNAi in S2 cells. Nawathean, P., Menet, J.S., and Rosbash, M. Methods In Enzymology 393:610-622 (2005).

Publications from 2004 (to top)

A synthetic A tail rescues yeast nuclear accumulation of a ribozyme-terminated transcript. Dower, K., Kupperwasser, N., Merrikh, H.,and Rosbash, M. RNA 10:1888-1899 (2004).

NMD does not occur within the yeast nucleus. Kuperwasser, N., Brogna, S., Dower, K., and Rosbash, M. RNA 10: 1907-1915 (2004).

Coupled oscillators control morning and evening locomotor activity behavior of Drosophila. Stoleru, D., Peng, Y., Agosto, J., and Rosbash M. Nature 431:862-868 (2004).

Effects of the U1C L13 Mutation and Temperature Regulation of Yeast Commitment Complex Formation. Du, H., Tardiff, D. F., Moore, M.J., and Rosbash, M. PNAS 101:14841-14846 (2004).

Biochemical analysis of TREX complex recruitment to intronless and intron-containing yeast genes. Abruzzi, K.C., Lacadie, S., and Rosbash M. EMBO J. 23:2620–2631 (2004).

Roles of the two Drosophila CRYPTOCHROME structural domains in circadian photoreception. Busza, A., Emery-Le, M., Rosbash, M., and Emery, P. Science 304:1503-1506 (2004).

The doubletime and CKII kinases collaborate to potentiate Drosophila PER transcriptional repressor activity. Nawathean, P. and Rosbash, M. Mol Cell, Mol Cell 13:213-223 (2004).

Publications from 2003 (to top)

The Co-evolution of Blue-Light Photoreception and Circadian Rhythms. Ghering, W. and Rosbash, M. J. Mol. Evol 57:S286-S289 (2003).

Drosophila free-running rhythms require intercellular communication. Peng, Y., Stoleru, D., Levine, J.D., Hall, J.C. and Rosbash, M. PLOS 1:32-40 (2003).

Localization of nuclear retained mRNAs in Saccharomyces cerevisiae. Thomsen, R., Libri, D., Boulay, J., Rosbash, M., and Heick Jensen, T. RNA 9:1049-1057 (2003).

A recessive mutant of Drosophila Clock reveals a role in circadian rhythm amplitude. Allada, R., Kadener, S., Nandakumar, N., and Rosbash, M. EMBO J. 22:3367-3375 (2003).

Circadian rhythms in Drosophila. Rosbash, M., Allada, R., McDonald, M., Peng, Y., and Zhao, J. (2003) In Novartis Foundation Symposium 253: Molecular Clocks and Light Signalling (eds. Chadwick, D.J., and Goode, J.A.), pp.223-237. John Wiley and Sons Ltd., Chichester, UK.

Drosophila Clock can generate ectopic circadian clocks. Zhao, J., Kilman, V., Keegan, K., Peng, Y., Emery, P., Rosbash, M., and Allada, R. Cell 113:755-766 (2003).

Early formation of mRNP: License for export or quality control. Heick Jensen, T. Dower, K., Libri, D., and Rosbash, M. Mol. Cell 11:1129-1138 (2003).

A biological clock. Rosbash, M. Daedalus 132: 27-36 (2003).

Co-transcriptional monitoring of mRNP formation. Heick Jensen, T., and Rosbash, M. Nature Structural Biology 10:10-12 (2003).

Publications from 2002 (to top)

A role for Casein Kinase 2alpha in the Drosophila circadian clock. Lin, J.M., Kilman, V.L., Keegan, K., Paddock, B., Emery-Le, M., Rosbash, M., and Allada R. Nature 420: 816-820 (2002).

Circadian rhythms: The cancer connection. Rosbash, M and Takahashi, J.S. Nature 420: 373-374 (2002).

Interactions between mRNA export commitment, 3’-end quality control and nuclear degradation. Libri, D., Dower, K., Boulay, J., Thomsen, R., Rosbash, M., and Jensen, T.H. MCB. 22:8254-8266 (2002).

The U1 snRNP protein U1C recognizes the 5' splice site in the absence of base pairing. Du, H. and Rosbash, M. Nature 419:86-92 (2002).

Ribosome components are associated with sites of transcription. Brogna, S., Sato, T.A., and Rosbash, M. Mol. Cell 10:93-104 (2002).

Sequential nuclear accumulation of the clock proteins period and timeless in the pacemaker neurons of Drosophila melanogaster. Shafer, O.T., Rosbash, M., and Truman, J.W. J. Neurosci. 22:5946-5954 (2002).

Regulation of alternative splicing by a transcriptional enhancer through RNA pol II elongation. Kadener, S., Fededa, J.P., Rosbash, M., and Kornblihtt, A.R. PNAS 99:8185-8190 (2002).

T7 RNA polymerase-directed transcripts are processed in yeast and link 3' end formation to mRNA nuclear export. Dower, K. and Rosbash, M. RNA 8:686-697 (2002).

Publications from 2001 (to top)

Microarray analysis and organization of circadian gene expression in Drosophila. McDonald, M. and Rosbash, M. Cell 107:567-578 (2001).

Cell Biology: TAPping into mRNA Export. Moore, M.J. and Rosbash, M. Science 294:1841-1842 (2001).

The DECD-box putative ATPase Sub2p is an early mRNA export factor. Heick-Jensen, T., Boulay, J., Rosbash, M., and Libri, D. Current Biol. 11:1711-1715 (2001).

Quality control of mRNA 3'-end processing is linked to the nuclear exosome. Hilleren, P., McCarthy, T., Rosbash, M., Parker, R., Jensen, T.H. Nature 413:538-542 (2001).

Recognition of RNA branchpoint sequences by SF1/mBBP in a splicing factor complex. Peled-Zehavi, Z., Berglund, J.A., Rosbash, M., and Frankel, A.D. Mol. Cell Bio. 21:5232-5241, (2001).

Crystal structure of a model branchpoint - U2 snRNA duplex containing bulged adenosines. Berglund, J.A., Rosbash, M., Schultz, S.C. RNA 7:682-691 (2001).

Stopping Time: The Genetics of Fly and Mouse Circadian Rhythms. Allada, R., Emery, P., Takahashi, J.S. and Rosbash, M. Ann. Rev. Neurosci. 24:1091-1119 (2001).

A block to mRNA nuclear export in S. cerevisiae leads to hyperadenylation of transcripts that accumulate at the site of transcription. Heick-Jensen, T., Patricio, K., McCarthy, T., and Rosbash, M. Mol. Cell 7:887-898 (2001).

Fly Clocks: The Molecular Genetics of Circadian Rhythms. Allada, R. and Rosbash, M. (2001). In Genetic Models in Cardiorespiratory Biology (eds. Haddad, G.G., and Tian, X.), pp.365-390. Marcel Dekker, Inc., New York, NY.

Yeast U1 snRNP-pre-mRNA complex formation without U1 snRNP-pre-mRNA base pairing. Du, H., and Rosbash, M. RNA 7:133-142 (2001).

A Biochemical Function for the Sm Complex. Zhang, D., Abovich, N., Rosbash, M. Mol. Cell 7:319-329 (2001).

Wild-type circadian rhythmicity is dependent on closely spaced E-boxes in the Drosophila timeless promoter. McDonald, M., Rosbash, M., Emery, P. Mol. Cell Biol. 21:1207-1217 (2001).

Publications from 2000 (to top)

A common core RNP structure shared between the small nucleolar box C/D RNPs and the spliceosomal U4 snRNP. Watkins, N.J., Segauly, V., Charpentier, B., Nottrott, S., Fabrizio, P., Bachi, A., Wilm, M., Rosbash, M., Branlant, C., Luhrmann, R. Cell 103:457-466 (2000).

Identification of novel Saccharomyces cerevisiae proteins with nuclear export activity: Cell cycle-regulated transcription factor Ace2p shows cell cycle-independent nucleocytoplasmic shuttling. Heick-Jensen, T., Neville, M., Rain, J.C., McCarthy, T., Legrain, P. and Rosbash, M. Mol. Cell Biol. 20:8047-8058 (2000).

Two novel doubletime mutants alter circadian properties and eliminate the delay between RNA and protein in Drosophila. Suri, V., Hall, J. and Rosbash, M. J. Neurosci. 20:7547-7555 (2000).

takeout, a Novel Drosophila Gene under Circadian Clock Transcriptional Regulation. So, W.V., Sarov-Blat, L., Kotarski, C.K., McDonald, M.J., Allada, R., and Rosbash, M. Mol. Cell Biol. 20:6935-6944 (2000).

The Drosophila takeout gene is a novel molecular link between circadian rhythms and feeding behavior. Sarov-Blat, L., So, W. V., Liu, L., and Rosbash, M. Cell 101:647-656 (2000).

Drosophila CRY is a deep brain circadian photoreceptor. Emery, P., Stanewsky, R., Helfrich-Forster, C., Emery-Le, M., Hall, J. C., and Rosbash, M. Neuron 26:493-504 (2000).

Nuclear export of heat shock and non-heat-shock mRNA occurs via similar pathways. Vainberg, I. E., Dower, K., and Rosbash, M. Mol.Cell Biol. 20:3996-4005 (2000).

A unique circadian-rhythm photoreceptor. Emery, P., Stanewsky, R., Hall, J. C., and Rosbash, M. Nature 404:456-457 (2000).

Splicing enhancement in the yeast rp51b intron. Libri, D., Lescure, A., and Rosbash, M. RNA 6:352-368 (2000).

Differential regulation of circadian pacemaker output by separate clock genes in Drosophila. Park, J. H., Helfrich-Forster, C., Lee, G., Liu, L., Rosbash, M., and Hall, J. C. Proc.Natl.Acad.Sci.U.S.A 97:3608-3613 (2000).

Publications from 1999 (to top)

A pdf neuropeptide gene mutation and ablation of PDF neurons each cause severe abnormalities of behavioral circadian rhythms in Drosophila. Renn, S. C., Park, J. H., Rosbash, M., Hall, J. C., and Taghert, P. H. Cell 99:791-802 (1999).

The RNA export factor Gle1p is located on the cytoplasmic fibrils of the NPC and physically interacts with the FG-nucleoporin Rip1p, the DEAD-box protein Rat8p/Dbp5p and a new protein Ymr255p. Strahm, Y., Fahrenkrog, B., Zenklusen, D., Rychner, E., Kantor, J., Rosbash, M., Stutz, F. EMBO J. 18:5761-5777 (1999).

The NES-Crm1p export pathway is not a major mRNA export route in Saccharomyces cerevisiae. Neville, M. and Rosbash, M. EMBO J 18:3746-3756 (1999).

Identification of eight proteins that cross-link to pre-mRNA in the yeast commitment complex. Zhang, D. and Rosbash, M. Genes Dev. 13:581-592 (1999).

TIMELESS-dependent positive and negative autoregulation in the Drosophila circadian clock. Suri, V., Lanjuin, A., and Rosbash, M. EMBO J 18:675-686 (1999).

Publications from 1998 (to top)

The cryb mutation identifies cryptochrome as a circadian photoreceptor in Drosophila. Stanewsky, R., Kaneko, M., Emery, P., Beretta, B., Wager-Smith, K., Kay, S. A., Rosbash, M., and Hall, J. C. Cell 95:681-692 (1998).

CRY, a Drosophila clock and light-regulated cryptochrome, is a major contributor to circadian rhythm resetting and photosensitivity. Emery, P., So, W. V., Kaneko, M., Hall, J. C., and Rosbash, M. Cell 95:669-679 (1998).

Nuclear RNA export. Stutz, F. and Rosbash, M. Genes Dev. 12:3303-3319 (1998).

The timSL mutant affects a restricted portion of the Drosophila melanogaster circadian cycle. Rutila, J. E., Maltseva, O., and Rosbash, M. J Biol.Rhythms 13:380-392 (1998).

The KH domain of the branchpoint sequence binding protein determines specificity for the pre-mRNA branchpoint sequence. Berglund, J. A., Fleming, M. L., and Rosbash, M. RNA 4:998-1006 (1998).

Synthetic lethal/enhancer screening to identify snRNA:protein and protein:protein interactions in yeast pre-mRNA splicing. Stutz, F., Tang, J., and Rosbash, M. In RNA-Protein Interactions: A Practical Approach. (ed. Smith, C.) Ch 6:161-182 (1998).

Evidence that the TIM light response is relevant to light-induced phase shifts in Drosophila melanogaster. Suri, V., Qian, Z., Hall, J. C., and Rosbash, M. Neuron 21:225-234 (1998).

Why the rat-1 fibroblast should replace the SCN as the in vitro model of choice. Rosbash, M. Cell 93:917-919 (1998).

A comprehensive biochemical and genetic analysis of the yeast U1 snRNP reveals five novel proteins. Gottschalk, A., Tang, J., Puig, O., Salgado, J., Neubauer, G., Colot, H. V., Mann, M., Seraphin, B., Rosbash, M., Luhrmann, R., and Fabrizio, P. RNA 4:374-393 (1998).

CYCLE is a second bHLH-PAS clock protein essential for circadian rhythmicity and transcription of Drosophila period and timeless. Rutila, J. E., Suri, V., Le, M., So, W. V., Rosbash, M., and Hall, J. C. Cell 93:805-814 (1998).

A mutant Drosophila homolog of mammalian Clock disrupts circadian rhythms and transcription of period and timeless. Allada, R., White, N. E., So, W. V., Hall, J. C., and Rosbash, M. Cell 93:791-804 (1998).

Molecular coevolution within a Drosophila clock gene. Peixoto, A. A., Hennessy, J. M., Townson, I., Hasan, G., Rosbash, M., Costa, R., and Kyriacou, C. P. Proc.Natl.Acad.Sci.U.S.A 95:4475-4480 (1998).

A cooperative interaction between U2AF65 and mBBP/SF1 facilitates branchpoint region recognition. Berglund, J. A., Abovich, N., and Rosbash, M. Genes Dev. 12:858-867 (1998).

Publications from 1997 (to top)

Post-transcriptional regulation contributes to Drosophila clock gene mRNA cycling. So, W. V. and Rosbash, M. EMBO J 16:7146-7155 (1997).

The importin-beta family member Crm1p bridges the interaction between Rev and the nuclear pore complex during nuclear export. Neville, M., Stutz, F., Lee, L., Davis, L. I., and Rosbash, M. Curr.Biol. 7 :767-775 (1997).

The yeast nucleoporin rip1p contributes to multiple export pathways with no essential role for its FG-repeat region. Stutz, F., Kantor, J., Zhang, D., McCarthy, T., Neville, M., and Rosbash, M. Genes Dev. 11:2857-2868 (1997).

Identification and characterization of a yeast homolog of U1 snRNP- specific protein C. Tang, J., Abovich, N., Fleming, M. L., Seraphin, B., and Rosbash, M. EMBO J 16:4082-4091 (1997).

A new gene encoding a putative transcription factor regulated by the Drosophila circadian clock. Rouyer, F., Rachidi, M., Pikielny, C., and Rosbash, M. EMBO J 16:3944-3954 (1997).

The splicing factor BBP interacts specifically with the pre-mRNA branchpoint sequence UACUAAC. Berglund, J. A., Chua, K., Abovich, N., Reed, R., and Rosbash, M. Cell 89:781-787 (1997).

Cross-intron bridging interactions in the yeast commitment complex are conserved in mammals. Abovich, N. and Rosbash, M. Cell 89:403-412 (1997).

Circadian cycling of a PERIOD-beta-galactosidase fusion protein in Drosophila: evidence for cyclical degradation. Dembinska, M. E., Stanewsky, R., Hall, J. C., and Rosbash, M. J Biol.Rhythms 12:157-172 (1997).

A dynamic in vivo view of the HIV-I Rev-RRE interaction. Charpentier, B., Stutz, F., and Rosbash, M. J Mol.Biol. 266:950-962 (1997).

A high affinity binding site for the HIV-1 nucleocapsid protein. Berglund, J. A., Charpentier, B., and Rosbash, M. Nucleic Acids Res. 25:1042-1049 (1997).

Temporal and spatial expression patterns of transgenes containing increasing amounts of the Drosophila clock gene period and a lacZ reporter: mapping elements of the PER protein involved in circadian cycling. Stanewsky, R., Frisch, B., Brandes, C., Hamblen-Coyle, M. J., Rosbash, M., and Hall, J. C. J Neurosci. 17:676-696 (1997).

Publications from 1996 (to top)

Molecular Control of Circadian Rhythms. Rosbash, M., Rutila, J., Zeng, H. In Circadian Organization and Oscillatory Coupling (eds. Hiroshige, T., and Honma, K.-I.), Ch. 2, pp. 25-38. Hokkaido University Press: Sapporo (1996).

Effect of constant light and circadian entrainment of perS flies: evidence for light-mediated delay of the negative feedback loop in Drosophila. Marrus, S. B., Zeng, H., and Rosbash, M. EMBO J 15:6877-6886 (1996).

Yeast pre-mRNA is composed of two populations with distinct kinetic properties. Elliott, D. J. and Rosbash, M. Exp.Cell Res. 229:181-188 (1996).

A role for nucleoporin FG repeat domains in export of human immunodeficiency virus type 1 Rev protein and RNA from the nucleus. Stutz, F., Izaurralde, E., Mattaj, I. W., and Rosbash, M. Mol.Cell Biol. 16:7144-7150 (1996).

The timSL mutant of the Drosophila rhythm gene timeless manifests allele-specific interactions with period gene mutants. Rutila, J. E., Zeng, H., Le, M., Curtin, K. D., Hall, J. C., and Rosbash, M. Neuron 17:921-929 (1996).

Mixed mechanisms in yeast pre-mRNA splicing? Rosbash, M. Cell 87:357-359 (1996).

Characterization of yeast U1 snRNP A protein: identification of the N- terminal RNA binding domain (RBD) binding site and evidence that the C- terminal RBD functions in splicing. Tang, J. and Rosbash, M. RNA 2:1058-1070 (1996).

The yeast splicing factor Mud13p is a commitment complex component and corresponds to CBP20, the small subunit of the nuclear cap-binding complex. Colot, H. V., Stutz, F., and Rosbash, M. Genes Dev. 10 :1699-1708 (1996).

Intramolecular structure in yeast introns aids the early steps of in vitro spliceosome assembly. Charpentier, B. and Rosbash, M. RNA 2:509-522 (1996).

Identification and characterization of a yeast gene encoding the U2 small nuclear ribonucleoprotein particle B" protein. Tang, J., Abovich, N., and Rosbash, M. Mol.Cell Biol. 16:2787-2795 (1996).

A light-entrainment mechanism for the Drosophila circadian clock. Zeng, H., Qian, Z., Myers, M. P., and Rosbash, M. Nature 380:129-135 (1996).

A Drosophila circadian clock. Rosbash, M., Allada, R., Dembinska, M., Guo, W. Q., Le, M., Marrus, S., Qian, Z., Rutila, J., Yaglom, J., and Zeng, H. Cold Spring Harb.Symp.Quant.Biol. 61:265-278 (1996).