• Olivier-Mason A, Wojtyniak M, Bowie RV, Nechipurenko IV, Blacque OE, Sengupta P. (2013) Transmembrane protein OSTA-1 shapes sensory cilia morphology via regulation of intracellular membrane trafficking in C. elegans. Development. 140: 1560-1572 [PubMed]
• Hall SE, Chirn GW, Lau NC, Sengupta P. (2013) RNAi pathways contribute to developmental history-dependent phenotypic plasticity in C. elegans. RNA. 19: 306-19 [PubMed]
• Kaplan OI*, Doroquez DB*, Cevik S, Bowie RV, Clarke L, Sanders AA, Kida K, Rappoport JZ, Sengupta P, Blacque OE. (2012) Endocytosis genes facilitate protein and membrane transport in C. elegans sensory cilia. Curr Biol. 22: 451-60 [PubMed]
• Wright KJ, Baye LM, Olivier-Mason A, Mukhopadhyay S, Sang L, Kwong M, Wang W, Pretorius PR, Sheffield VC, Sengupta P, Slusarski DC, Jackson PK, (2011) An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium. Genes Dev. 25: 2347-60 [PubMed]
• Kim, K., Kim, R. and Sengupta, P. (2010) The HMX.NKX homeodomain protein MLS-2 specifies the identity of the AWC sensory neuron type via regulation of the ceh-36 Otx gene in C. elegans. Development. 137: 963-74 [PubMed]
• Hall, S. E.*, Beverly, M.B.*, Russ, C., Nusbaum, C. and Sengupta, P. (2010) A cellular memory of developmental history generates phenotypic diversity in C. elegans. Curr. Biol. 29:149-155. [PubMed] *equal contributions
• Nokes EB, Van Der Linden AM, Winslow C, Mukhopadhyay S, Ma K, Sengupta P. (2009) Cis-regulatory mechanisms of gene expression in an olfactory neuron type in Caenorhabditis elegans. Dev Dyn. 238: 3080-3092. [PubMed]
• Mukhopadhyay, S., Lu, Y., Shaham, S., and Sengupta, P. (2008). Sensory signaling-dependent remodeling of olfactory cilia architecture in C. elegans. Dev Cell 14, 762-774. [PubMed]
• Omori, Y., Zhao, C., Saras, A., Mukhopadhyay, S., Kim, W., Furukawa, T., Sengupta, P., Veraksa, A., and Malicki, J. (2008). Elipsa is an early determinant of ciliogenesis that links the IFT particle to membrane-associated small GTPase Rab8. Nat Cell Biol 10, 437-444. [PubMed]
• Bauer Huang, S.L., Saheki, Y., VanHoven, M.K., Torayama, I., Ishihara, T., Katsura, I., van der Linden, A., Sengupta, P., and Bargmann, C.I. (2007). Left-right olfactory asymmetry results from antagonistic functions of voltage-activated calcium channels and the Raw repeat protein OLRN-1 in C. elegans. Neural Develop 2, 24. [PubMed]
• Mukhopadhyay, S., Lu, Y., Qin, H., Lanjuin, A., Shaham, S., and Sengupta, P. (2007). Distinct IFT mechanisms contribute to the generation of ciliary structural diversity in C. elegans. EMBO J 26, 2966-2980. [PubMed]
• Lanjuin, A., Claggett, J., Shibuya, M., Hunter, C.P., and Sengupta, P. (2006). Regulation of neuronal lineage decisions by the HES-related bHLH protein REF-1. Dev Biol 290, 139-151. [PubMed]
• Kim, K., Colosimo, M.E., Yeung, H., and Sengupta, P. (2005). The UNC-3 Olf/EBF protein represses alternate neuronal programs to specify chemosensory neuron identity. Dev Biol 286, 136-148. [PubMed]
• Melkman, T., and Sengupta, P. (2005). Regulation of chemosensory and GABAergic motor neuron development by the C. elegans Aristaless/Arx homolog alr-1. Development 132, 1935-1949. [PubMed]
• Colosimo, M.E., Tran, S., and Sengupta, P. (2003). The divergent orphan nuclear receptor ODR-7 regulates olfactory neuron gene expression via multiple mechanisms in Caenorhabditis elegans. Genetics 165, 1779-1791. [PubMed]
• Lanjuin, A., VanHoven, M.K., Bargmann, C.I., Thompson, J.K., and Sengupta, P. (2003). Otx/otd homeobox genes specify distinct sensory neuron identities in C. elegans. Dev Cell 5, 621-633. [PubMed]
• Lanjuin, A., and Sengupta, P. (2002). Regulation of chemosensory receptor expression and sensory signaling by the KIN-29 Ser/Thr kinase. Neuron 33, 369-381. [PubMed]
• Colosimo, M.E., Brown, A., Mukhopadhyay, S., Gabel, C., Lanjuin, A.E., Samuel, A.D., and Sengupta, P. (2004). Identification of thermosensory and olfactory neuron-specific genes via expression profiling of single neuron types. Curr Biol 14, 2245-2251. [PubMed]
• Satterlee, J.S., Sasakura, H., Kuhara, A., Berkeley, M., Mori, I., and Sengupta, P. (2001). Specification of thermosensory neuron fate in C. elegans requires ttx-1, a homolog of otd/Otx. Neuron 31, 943-956. [PubMed]
• Sarafi-Reinach, T.R., Melkman, T., Hobert, O., and Sengupta, P. (2001). The lin-11 LIM homeobox gene specifies olfactory and chemosensory neuron fates in C. elegans. Development 128, 3269-3281. [PubMed]
• Sarafi-Reinach, T.R., and Sengupta, P. (2000). The forkhead domain gene unc-130 generates chemosensory neuron diversity in C. elegans. Genes Dev 14, 2472-2485. [PubMed]
• Miyabayashi, T., Palfreyman, M.T., Sluder, A.E., Slack, F., and Sengupta, P. (1999). Expression and function of members of a divergent nuclear receptor family in Caenorhabditis elegans. Dev Biol 215, 314-331. [PubMed]

Reviews

• Sengupta P, Schedl T. (2011) Cellular reprogramming: chromatin puts on the brake. Curr Biol. 22: R157-9 [PubMed]
• Lanjuin, A., and Sengupta, P. (2004). Specification of chemosensory neuron subtype identities in Caenorhabditis elegans. Curr Opin Neurobiol 14, 22-30. (Review) [PubMed]
• Sengupta, P. (2004). Taking sides in the nervous system with miRNA. Nat Neurosci 7, 100-102. (Review) [PubMed]
• Melkman, T., and Sengupta, P. (2004). The worm's sense of smell. Development of functional diversity in the chemosensory system of Caenorhabditis elegans. Dev Biol 265, 302-319. (Review) [PubMed]

[Back to Top]

• Jang, H, Kim K, Neal SJ, Mocosko E, Kim D, Butcher RA, Zeiger DM, Bargmann CI, Sengupta P. (2012) Neuromodulatory state and sex specify alternative behaviors through antagonistic synaptic pathways in C. elegans. Neuron. 75: 585-92 [PubMed]

• Expression of an sra-6::gfp transgene is reduced in the ASH and ASI sensory neurons of daf-8(oy8) mutants. (Nolan et al., 2002)

  Kim K, Sato K, Shibuya M, Zeiger DM, Butcher RA, Ragains JR, Clardy J, Touhara K, Sengupta P (2009) Two Chemoreceptors Mediate Developmental Effects of Dauer Pheromone in C. elegans. Science. 326: 994-998. [PubMed]
• van der Linden, A.M., Wiener, S., You, Y-J., Kim, K., Avery L., and Sengupta, P. (2008) The EGL-4 PKG acts with the KIN-29 SIK and KIN-2 PKA to regulate chemoreceptor gene expression and sensory behaviors in C. elegans. Genetics. 180, 1475-91. [PubMed]
• van der Linden, A.M., Nolan, K.M., and Sengupta, P. (2007). KIN-29 SIK regulates chemoreceptor gene expression via an MEF2 transcription factor and a class II HDAC. EMBO J 26, 358-370. [PubMed]
• Fujiwara, M., Sengupta, P., and McIntire, S.L. (2002). Regulation of body size and behavioral state of C. elegans by sensory perception and the EGL-4 cGMP-dependent protein kinase. Neuron 36, 1091-1102. [PubMed]
• Nolan, K.M., Sarafi-Reinach, T.R., Horne, J.G., Saffer, A.M., and Sengupta, P. (2002). The DAF-7 TGF-beta signaling pathway regulates chemosensory receptor gene expression in C. elegans. Genes Dev 16, 3061-3073. [PubMed]
• Lanjuin, A., and Sengupta, P. (2002) The KIN-29 Ser/Thr kinase regulates chemosensory receptor expression and neuroendocrine signaling in C. elegans. Neuron 33, 369-81. [PubMed]
• Chou, J.H., Bargmann, C.I., and Sengupta, P. (2001). The Caenorhabditis elegans odr-2 gene encodes a novel Ly-6-related protein required for olfaction. Genetics 157, 211-224. [PubMed]
• Daniels, S.A., Ailion, M., Thomas, J.H., and Sengupta, P. (2000). egl-4 acts through a transforming growth factor-beta/SMAD pathway in Caenorhabditis elegans to regulate multiple neuronal circuits in response to sensory cues. Genetics 156, 123-141. [PubMed]
• Sengupta, P. and Carlson, J. (2000) Genetic models in chemoreception in Neurobiology of Taste and Smell. (T.E. Finger, W.L. Silver and D. Restrepo, eds.) pp 41-72. Wiley Press, New York, USA.

Reviews

• Neal SJ, Kim K, Sengupta P. 2012. Quantitative assessment of pheromone-induced dauer formation Caenorhabditis elegans. Methods in Molecular Biology. In Press.
• Sengupta, P. (2012) The belly rules the nose: feeding state-dependent modulation of peripheral chemosensory responses. Curr Opin Neurobiol. [epub ahead of print]. [PubMed]
• Sengupta, P. (2007). Smell: the worm turns. Nature 450, 35-36. (Review) [PubMed]
• Sengupta, P., and Thomas, J.H. (2007). From eye of newt to chemical structure. Nat Chem Biol 3, 368-369. (Review) [PubMed]
• Sengupta, P. (2007). Generation and modulation of chemosensory behaviors in C. elegans. Pflugers Arch 454, 721-734. (Review) [PubMed]
• Sengupta, P. (2002). Chemosensation: tasting with the tail. Curr Biol 12, R386-388. (Review) [PubMed]
• Sengupta, P. (1997). Cellular and molecular analyses of olfactory behavior in C. elegans. Semin Cell Dev Biol 8, 153-161. (Review) [PubMed]

[Back to Top]

• Isothermal tracks made by wild-type worms cultivated overnight at 20°C and placed on a thermal gradient. (Biron et al., 2006)

  Beverly M, Anbil S, Sengupta P. (2011) Degeneracy and neuromodulation among thermosensory neurons contribute to robust thermosensory behaviors in Caenorhabditis elegans. J Neurosci. 31, 11718-27. [PubMed]
• Wasserman SM, Beverly M, Bell HW, Sengupta P. (2011) Regulation of Response Properties and Operating Range of the AFD Thermosensory Neurons by cGMP Signaling. Curr Biol. 21, 353-62. [PubMed]
• van der Linden AM*, Beverly M, Kadener S, Rodriguez J, Wasserman S, Rosbash M, Sengupta P* (2010) Genome-wide analysis of light and temperature-entrained circadian transcripts in C. elegans. Plos Biology. 8, e1000503 *co-corresponding authors. [PubMed]
• Biron, D.*, Wasserman, S.*, Thomas, J.H., Samuel, A.D., and Sengupta, P. (2008). An olfactory neuron responds stochastically to temperature and modulates Caenorhabditis elegans thermotactic behavior. Proc Natl Acad Sci U S A 105, 11002-11007. [PubMed] (*equal contributors)
• Chi, C.A., Clark, D.A., Lee, S., Biron, D., Luo, L., Gabel, C.V., Brown, J., Sengupta, P., and Samuel, A.D. (2007). Temperature and food mediate long-term thermotactic behavioral plasticity by association-independent mechanisms in C. elegans. J Exp Biol 210, 4043-4052. [PubMed]
• Biron, D., Shibuya, M., Gabel, C., Wasserman, S.M., Clark, D.A., Brown, A., Sengupta, P., and Samuel, A.D. (2006). A diacylglycerol kinase modulates long-term thermotactic behavioral plasticity in C. elegans. Nat Neurosci 9, 1499-1505. [PubMed]
• Clark, D.A., Biron, D., Sengupta, P., and Samuel, A.D. (2006). The AFD sensory neurons encode multiple functions underlying thermotactic behavior in Caenorhabditis elegans. J Neurosci 26, 7444-7451. [PubMed]
• Inada, H., Ito, H., Satterlee, J., Sengupta, P., Matsumoto, K., and Mori, I. (2006). Identification of guanylyl cyclases that function in thermosensory neurons of Caenorhabditis elegans. Genetics 172, 2239-2252. [PubMed]
• Samuel, A.D., and Sengupta, P. (2005). Sensorimotor integration: locating locomotion in neural circuits. Curr Biol 15, R341-343. [PubMed]
• Colosimo, M.E., Brown, A., Mukhopadhyay, S., Gabel, C., Lanjuin, A.E., Samuel, A.D., and Sengupta, P. (2004). Identification of thermosensory and olfactory neuron-specific genes via expression profiling of single neuron types. Curr Biol 14, 2245-2251. [PubMed]
• Satterlee, J.S., Ryu, W.S., and Sengupta, P. (2004). The CMK-1 CaMKI and the TAX-4 Cyclic nucleotide-gated channel regulate thermosensory neuron gene expression and function in C. elegans. Curr Biol 14, 62-68. [PubMed]

Reviews

• Garrity, P., Goodman, M.B., Samuel. A.D. and Sengupta, P. (2010) Running hot and cold: behavioral strategies, neural circuits and the molecular machinery for thermotaxis in C. elegans and Drosophila. Genes Dev, 24, 2365-82. [PubMed]
• Sengupta, P. and Samuel, A.D. (2009) C. elegans: a model system for systems neuroscience. Curr. Opin. Neurobiol.19: 637-43. [PubMed]

[Back to Top]