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| Mutations in the human Arx gene have been linked to neurodevelopmental disorders. Diseases arising from Arx mutations include X-linked lissencephaly with ambiguous genitalia (XLAG), Proud syndrome, non-syndromic mental retardation (MRX), and mental retardation and autism. I am interested in exploring the mechanistic functions of Arx, and its C. elegans homolog (alr-1). I will use both the mouse and C. elegans models to study the role of Arx/alr-1 in neuronal development. | |