Stabilization of specific synaptic contacts during development is thought to contribute to activity-dependent circuit development, but the molecular mechanisms that lead to synapse stabilization are poorly understood. Previous work in our lab has shown that CaMKII plays a role in strengthening existing synapses as well as selectively promoting an increase in new contact formation between pairs of neurons (Pratt et al., 2003; Pratt, Taft et al., 2008). We are using time-lapse imaging to examine how CaMKII phosphorylation and PSD-95 expression can stabilize axodendritic (AD) contacts between neocortical neurons.
Roles of PSD-95 and CaMKII in Synaptic Remodeling
blocks_image
blocks_image