Visual deprivation induces profound changes in visual response properties. Monocular deprivation induces an initial decrease in responsiveness of cortical neurons to the deprived eye and a slower potentiation in the responsiveness to the non-deprived eye, but the activity-dependent plasticity mechanisms underlying this delayed potentiation are poorly understood.

We are currently investigating whether changes in the balance of excitation and inhibition and/or changes in intrinsic excitability underlie the delayed potentiation induced by monocular deprivation. In addition, we are using immunohistochemistry to assess network activity levels in visual cortex during visual deprivation.
Experience-dependent plasticity induced by prolonged monocular deprivation