Disrupted Synaptic Scaling in Rett Syndrome
Rett Syndrome (RTT) is an X-linked neurodevelopment disorder and is one of the leading causes of mental retardation in females. RTT is a monogenic disease and most cases are due to mutations in the gene coding for methyl-CpG binding protein 2 (MeCP2).

Despite knowing the genetic cause of RTT, very little is known about the underlying brain defects. Several studies have suggested that homeostatic plasticity mechanisms that stabilize the activity of neurons and circuits may be perturbed in RTT. In collaboration with Sasha Nelson’s lab we are examining the possibility that MeCP2 may be essential for the expression of one form of homeostatic plasticity, synaptic scaling. We are also currently working on determining the molecular mechanisms and targets of MeCP2 involvement in scaling.
More Information on Rett Syndrome can be found HERE