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Undergraduate Authors in the Life Sciences

One of the most valuable aspects of a Brandeis education in the Life Sciences is the opportunity to carry out cutting-edge research in the laboratories of our faculty in Biology, Biochemistry, Biophysics, Neuroscience and related fields.  Some students begin working in labs as early as their first semester, and many start as juniors, leading up to a senior Honors Thesis.  Since 1999, Brandeis 76 undergraduates have been co-authors on 73 peer-reviewed research publications. 

2007

Names of undergraduate students are shown in bold

  • "Targeting a prokaryotic protein in a eukaryotic pathogen:  identification of lead compounds against Cryptosporidiosis." Umejiego, N.N.;  Gollapalli, D.;  Sharling, L.; Volftsun, A.; Lu, J.; Benjamin, N.N.; Stroupe, A.H.;  Riera1, T.V.; Striepen, B.; Hedstrom, L.. Chem. Biol., in press.

  • "Non-cell-autonomous regulation of GABAergic neuron development by neurotrophins and the p75 receptor." Lin P.Y.; Hinterneder J.M.; Rollor S.R.; Birren S.J. (2007 Nov 21) J Neurosci., 27(47):12787-96.

  • "Fruitless gene products with female-like qualities  promote neural and behavioral maleness in Drosophila if these truncated proteins are  produced in the right places at the right times." Ferri, S.L.; Rohm R.A.; Lincicome H.E.; Hall J.C.; and Villella, A. J. Neurogenet. In press.

  • "BMP2 induction of GFAP uses SMAD, MEDK1/2/ERK, and PI3K signaling pathways and involves AP1 and SP1 interactions." Dore, J.J.; DeWitt, J.C.; Chesarone, M.A; and Birren, S.J. (2007). In revision.

  • "Transcriptional Feedback and Definitions of the Circadian Pacemaker in Drosoophila and Animals."  Rosbash M.; Bradley S.; Kadener S.; Liu Y.; Menet J.; Nagoshi E.; Palm K.; Schoer R.; Shang Y; and Tang A. (2007).

  • "Learning-related plasticity of temporal coding in simultaneously-recorded amygdala-cortical ensembles." Grossman, S. A.; Fontanini, A.; Wieskopf, J. S.; & Katz, D. B. (2007).Provisionally accepted, pending appropriate revision. Journal of Neuroscience.

  • "Investigating the motivational mechanism of altered saline consumption following 5-HT_1A manipulation". Caras, M.; MacKenzie, K. J.; Rodwin, B.;& Katz, D. B. (2007). Revised mss submitted to Behavioral Neuroscience.

  • "Single-cell duplex RT-LATE-PCR reveals Oct4 and Xist RNA gradients in 8-cell embryos." Hartshorn C.; Eckert J.J.; Hartung O.; and Wangh L.J. (2007) BMC Biotechnology, 7:87.

  • "Early Onset of Heat-Shock Response in Mouse Embryos Revealed by Quantifi cation of Stress-Inducible hsp70i RNA." Hartshorn C.; Anshelevich A; Jia Y; and Wangh.L.J. (2007).Gene Regulation and Systems Biology 2007, 1 1–9.

  • “Nickel in acireductone dioxygenase.” Pochapsky T.C.; Ju T.; OuYang B.; Dang M.; Beaulieu R.; and Pagani G.M. (2007) in "Nickel and Its Surprising Impact in Nature", Vol. 2 of 'Metal Ions in Life Sciences';  A. Sigel, H. Sigel, R. K. O. Sigel, Eds.; John Wiley & Sons, Ltd., Chichester, UK, pp. 473-500.

2006

  • "Targeted Degradation of the AML1/MDS1/EVI1 oncoprotein by Arsenic Trioxide". Shackelford, D.; Kenific, C.; Blusztajn, A.; Waxman S.; and R. Ren. (2006) Cancer Research. 66:11360-11369.

  • "Calcium-dependent gating of MthK, a prokaryotic potassium channel". Zadek, B. and Nimigean, C.M. (2006) J. Gen. Physiol.127:673-685.

  • "Two-temperature LATE-PCR endpoint genotyping". Sanchez, J. A.; Abramowitz, J.D.; Salk, J.J.; Reis, Jr, A.H.; Rice, J.E.; Pierce, K.E.; and Wangh, L.J. (2006), BMC Biotechnology, 6:44.

  • "Direct Amplification of Single-Stranded DNA for Pyrosequencing using Linear-After-The-Exponential (LATE)-PCR". Salk J.J.; Sanchez J.A.; Pierce K.E.; Rice J.E.; Soares K.C.; Wangh L.J. (2006) Analytical Biochemistry, Volume 353, Issue 1, 1 June 2006, Pages 124-132.

  • "Aip1 and cofilin promote rapid turnover of yeast actin patches and cables: a coordinated mechanism for severing and capping filaments". Okada, K.; Ravi H.; Smith E.; and Goode B.L. (2006). Mol. Biol. Cell. 17:2855-2868.

  • "Molecular taxonomy of major neuronal classes in the adult mouse forebrain". Sugino K.; Hempel C.M.; Miller M.; Hattox A.M.; Shapiro P.; Wu C.; Huang Z.H.  and Nelson S.B. (2006) Nat. Neurosci. 9:99-107.  

  • "DNA Repeat Rearrangements Mediated by DnaK Dependent Replication Fork Repair", Goldfless S.J.; Morag A.S.; Belisle K.A.;, Sutera V.A. Jr; Lovett S.T., Mol Cell. (2006) Mar 3;21(5):595-604.

  • "Temporary basolateral amygdala lesions disrupt acquisition of socially transmitted food preferences in rats". Wang Y-Y;Fontanini A.; and Katz D.B. (2006) Learn Mem 13: 794-800.

  • "Cis and trans-acting effects on a mutational hotspot involving a replication template switch". Dutra B.E.; Lovett S.T. Journal of Molecular Biology. (2006 Feb 17);356(2):300-11.

  • “One protein, two enzymes revisited:  A structural entropy switch interconverts the two isoforms of acireductone dioxygenase.” Ju T.; Beaulieu Goldsmith R.; Chai S.C.; Maroney M.J.; Pochapsky S.S.; and Pochapsky T.C. (2006)  J. Mol. Biol. 393, 823-834.

2005

  • "RAD51-dependent break-induced replication differs in kinetics and checkpoint responses from RAD51-mediated gene conversion". Malkova A.; Naylor M.L.; Yamaguchi M.; Ira G.; and Haber J.E. (2005) Mol. Cell. Biol. 25: 933-944. 

  • "The UNC-3 Olf/EBF protein represses alternate neuronal programs to specify chemosensory neuron identity". Kim, Kyuhyung, Colosimo, M.E., Yeung, H. and Sengupta, P. (2005). Dev. Biol., 286:136-148.

  • "Constant amplitude of postsynaptic responses for single presynaptic action potentials but not bursting input during growth of an identified neuromuscular junction in the lobster, Homarus americanus." Pulver, S.R.; Bucher, D.; Simon, D.J.; and Marder, E. (2005) J. Neurobiol. 62: 47-61.

  • "Laser zona-drilling does not induce /hsp70i/ transcription in blastomeres of 8-cell mouse embryos". Hartshorn, C.; Anshelevich, A.; and Wangh, L.J. (2005) Fertility and Sterility,  84,1547-1550.

  • "Rapid, single-tube method for quantitative preparation and analysis of RNA and DNA in samples as small as one cell". Hartshorn C.; Anshelevich A.; Wangh L.J. (2005) . BMC Biotechnol, 5:2.

  • "Functional analysis of fruitless gene expression by transgenic manipulations of Drosophila courtship". Villella, A.; Ferri S.L.; Krystal J.D.; and Hall J.C. (2005) Proc. Nat. Acad. Sci. U.S. 102: 16550-16557.

  • " A bacterial G protein-mediated response to replication arrest". Foti J.J.; Schienda J.; Sutera V.A. Jr; Lovett S.T., Mol Cell. (2005 Feb 18) 17(4):549-60.

  • "Hippocampal inactivation enhances taste learning". Stone M.E.; Grimes B.S.; and Katz D.B. (2005) Learning & Memory 12: 579-586.

  • "Inhibition of Perforant Path Input to the CA1 Region by Serotonin and Noradrenaline". Otmakhova N.A.; Lewey J.; Asrican B.; Lisman J.E. (2005) Journal of Neurophysiology 94:1413-1422.

2004

  • "Gene conversion and crossing over along the 405-kb left arm of Saccharomyces cerevisiae chromosome VII". Malkova, A.; Swanson J.; German, M.; McCusker J.H.; Housworth E.A.; Stahl F.W.; and Haber J.E. (2004) Genetics 168: 49-63. 

  • "Diversity in the Rates of Transcript Elongation by Single RNA Polymerase Molecules". Tolič-Nørrelykke S.F., Engh A.M.; Landick R.; and Gelles J. (2004) J. Biol. Chem. 279: 3292-3299.

  • "Nitric oxide inhibits the rate and strength of cardiac contractions in the lobster Homarus americanus by acting on the cardiac ganglion". Mahadevan A.; Lappé J.; Rhyne R.; Cruz N.; Marder E.; and Goy M. (2004) J. Neurosci., 24: 2813-2824.

  • "Inosine 5'-monophosphate dehydrogenase binds nucleic acids in vitro and in vivo". McLean J.; Hamaguchi N.; Belenky P.; Mortimer S.E.; Stanton M. & Hedstrom, L. (2004) Biochemical Journal 379: 243-251.

  • "Substitution of the Conserved Arg-Tyr Dyad Selectively Disrupts the Hydrolysis Phase of the IMP Dehydrogenase Reaction". Schlippe G.; Yollete V.; Riera, T.V.; Seyedsayamdost, M.R.; and Hedstrom, L. (2004). Biochemistry 43:4511-4521. 

  • "A conserved mechanism for Bni1- and mDia1-induced actin assembly and dual regulation by Bud6 and profilin". Moseley, J.B.; Sagot I.; Manning A.L.; Xu Y.; Eck M.; Pellman D.; and Goode B.L. (2004). Mol. Biol. Cell 15:896-907.

  • "A high affinity interaction with ADP-actin monomers underlies the mechanism and in vivo function of Srv2/cyclase-associated protein". Mattila, P.; Quintero O.; Kugler J.; Moseley J.B.; Almo S.C.; Lappalainen P.; and Goode B.L. (2004). Mol. Biol. Cell. 15:5158-5171.

  • “Linkage between dynamics and catalysis in a thermophilic – mesophilic enzyme pair”. Wolf-Watz, M.; Thai, V.; Henzler-Wildman, K.; Hadjipavlou, G.; Eisenmesser E.Z.; and Kern, D. (2004). Nat. Struct. Mol. Biol., 11:945-949.

  • "Forskolin-induced LTP in the CA1 hippocampal region is NMDA-dependent." Otmakhov N.; Khibnick L.; Otmakhova N.; Carpenter S.; Riahi S.; Asrican B.; Lisman J. Journal of Neurophysiology 2004; 91:1955-1962.

  • "Persistent Accumulation of Calcium/Calmodulin-Dependent Protein Kinase II in Dendritic Spines after Induction of NMDA Receptor-Dependent Chemical Long-Term Potentiation." Otmakhov N.; Tao-Cheng J-H.; Carpenter S.; Asrican B.; Dosemici A.; Reese T.S.; Lisman J. Journal of Neuroscience, (2004), 24(42):9324-9331.

  • "Analogs of 1-phospho-2,3-dioxo-5-methylthiopentane, an acyclic intermediate in the methionine salvage pathway: a new preparation and characterization of activity with E1 enolase/phosphatase from Klebsiella oxytoca."  Zhang Y.; Heinsen M.; Kostic M.; Pagani G.; Hedstrom L.; Riera T.; Perovic I.; Snider B.B.; and Pochapsky T.C. (2004) Bioorganic and Medicinal Chemistry, 12, 3847-3855.

2003

  • "Electrostatic tuning of ion conductance in K+ channels." Nimigean, C.M.; Chappie, J.S.; and Miller, C. (2003)  Biochemistry 42:9263-9268. 

  • "Serotonin in the developing stomatogastric system of the lobster, Homarus americanus." Richards, K.S.; Simon, D.J.; Pulver, S.R.; Beltz, B.S.; and Marder, E. (2003) J. Neurobiol. 54: 380-392.

  • "Episodic bouts of activity accompany recovery of rhythmic output by a neuromodulator and activity-deprived adult neural network." Luther, J.A.; Robie, A.; Yarotsky, J.; Reina, C.; Marder, E.; and Golowasch, J. (2003) J Neurophysiol., 90: 2720-2730.

  • "A recessive mutant of Drosophila Clock reveals a role in circadian rhythm amplitude." Allada, R.; Kadener, S.; Nandakumar, N.; and Rosbash, M. (2003) EMBO J. 22:3367-3375.

  • "The immunosuppressive agent mizoribine monophosphate forms a transition state analog complex with IMP dehydrogenase." Gan L.; Seyedsayamdost M.R.; Shuto S.; Matsuda A.; Petsko G.A. & Hedstrom L. (2003) Biochemistry 42: 857-863.

  • "Negative regulation of yeast WASp by two SH3 domain-containing proteins." Rodal, A.A.; Manning A.L.; Goode B.L.; and Drubin D.G. (2003) Curr. Biol. 13:1-20.

  • "Coordinated regulation of actin filament turnover by a high molecular weight Srv2/CAP complex, cofilin, profilin, and Aip1." Balcer, H.I.; Goodman A.; Rodal A.A.; Smith E.; Kugler J.; Heuser J.E.; and Goode B.L. (2003). Curr. Biol. 13:2159-69.

  • "Dietary conjugated linoleic acid (CLA) lowers plasma cholesterol during cholesterol supplementation, but accentuates the atherogenic lipid profile of the acute phase response in hamsters." Sher J.; Pronczuk A.; Hajri T.; and Hayes K.C (2003). J Nutr 133: 456-460/

2002

  • "The DAF-7 TGF-? signaling pathway regulates chemosensory receptor gene expression in C. elegans. " Nolan K.M.; Sarafi-Reinach T.R.; Horne J.G.; Saffer A.M.; and Sengupta P. (2002) Genes Dev. 16:3061-73.

  • "Courtship and other behaviors affected by a heat-sensitive, molecularly novel mutation in the cacophony calcium-channel gene of Drosophila." Chan B.; Villella A.; Funes P.; and Hall J.C. (2002) Genetics 162:135-153.

  • "Glvceride stearic acid content and structure affect the energy available to growing rats." Treadwell R.M.; Pronczuk, A.; and Hayes K.C.  (2002) J. Nutr. 132: 3356-3362.

  • "Crossing over between regions of limited homology in Escherichia coli. RecA-dependent and RecA-independent pathways." Lovett S.T.; Hurley R.L.; Sutera V.A. Jr; Aubuchon R.H.; Lebedeva M.A. (2002). Genetics.Mar;160(3):851-9.

  • “Comparison of functional domains in vertebrate-type ferredoxins.” Kostic M.; Pochapsky T.C.; Pochapsky S.S.; Obenauer J.; Mo H.; Pagani G.M.; and Pejchal R. (2002) Biochemistry 41, 5978-5989.

2001

  • "The SH2 domain of Bcr-Abl is not required to induce a murine myeloproliferative disease; however, SH2 signaling influences disease latency and phenotype." Zhang X; Wong R.; Hao S.X.; Pear W.S.; and Ren R. (2001) Blood. 97: 277-287.

  • "The NH2-terminal coiled-coil domain and tyrosine 177 play important roles in induction of a myeloproliferative disease in mice by Bcr-Abl." Zhang X.; Subrahmanyam R.; Wong R.; Gross A.W.; and Ren R. (2001) Mol. Cell. Biol. 21: 840-853.

  • "A Saccharomyces servazzii clone homologous to Saccharomyces cerevisiae chromosome III spanning KAR4, ARS304 and SPB1 lacks the Recombination Enhancer but contains an unknown ORF." Zhou Z.; Sun K.; Lipstein E.A.; and Haber J.E. (2001) Yeast 18: 789-795.

  • "Genetic requirements for RAD51- and RAD54-independent break-induced replication repair of a chromosomal double-strand break." Signon, L.; Malkova A.; Naylor M.; and Haber J.E. (2001) Mol. Cell. Biol. 21: 2048–2056. 

  • "GABA enhances transmission at an excitatory glutamatergic synapse. " Gutovitz S.; Birmingham J.T.; Luther J.A.; Simon D.J.; and Marder, E. (2001) J. Neurosci., 21:5935-5943.

  • “Nonrandom Distribution of the Inactive X Chromosome in Human Neutrophil Nuclei”, Karni R.J.; Wangh L.J.; and Sanchez J. A.  (2001) Chromosoma 110: 267-274.

  • "Target interactions promote the functional maturation of neurons derived from a sympathetic precursor cell line." Bharmal S.; Slonimsky J.D.; Mead J.N.; Sampson C.P.B.; Tolkovsky A.M; Yang B.; Bargman R.; and Birren S.J. (2001) Dev. Neurosci. 23:153-164.

  • "Effects of mutations in potential phosphorylation sites on transcytosis of FcRn." McCarthy K.M.; Lam M.; Subramanian L.; Shakya R.; Wu Z.; Newton E.E.; and Simister N.E. (2001)  J. Cell Sci. 114:1591-1598.

  • "Redox-dependent conformational selection in a Cys4Fe2S2 ferredoxin.” Pochapsky T.C.; Kostic M.; Jain N.; and Pejchal R. (2001) Biochemistry. 40:5602-5614.

2000

  • "Multiple forms of short-term plasticity in rat prefrontal cortex. " Hempel C.M.; Hartman K.; Wang X.J.; Turrigiano G.G.; and Nelson S.B. (2000) J. Neurophysiol. 83:3031-41.

  • "A novel mutational hotspot in a natural quasipalindrome in Escherichia coli." Viswanathan M., Lacirignola J.J; Hurley R.; and Lovett S.T. (2000) J. Mol. Biol. 302: 553-564.

  • "Bidirectional transcytosis of IgG by the rat neonatal Fc receptor expressed in a rat kidney cell line: a system to study protein transport across epithelia." McCarthy K.M.; Yoong Y.L.; and Simister N.E. (2000).J. Cell Sci. 113:1277-1285.

  • "Cloning and analysis of the gene encoding the human neonatal Fc receptor." Mikulska J.E.; Pablo L.; Canel J.; and Simister N.E. (2000) Eur. J. Immunogenetics 27: 231-240.

  • "Inhibition of the cAMP pathway decreases early long-term potentiation at CA1 hippocampal synapses." Otmakhova N.; Otmakhov N.; Mortenson L.H.; and Lisman J.E. (2000) Journal of Neuroscience 20:4446-4451.

1999

  • "Polarized distribution of Bcr-Abl in migrating myeloid cells and co-localization of Bcr-Abl and its target proteins." Skourides, P.A.; Perera, S. A.; and Ren R. (1999) Oncogene. 18: 1165-1176.

  • "Role of yeast SIR proteins and mating type in directing DNA double-strand breaks to homologous or nonhomologous repair routes." Lee S.E.; Pâques F.; Sylvan J.; and Haber J.E. (1999) Curr. Biol. 9: 767-770.

  • "Helical structure and packing orientation of the S2 segment in the Shaker K+ channel."  Monks, S.; Needleman D.; and Miller C. (1999)  J. Gen. Physiol. 113: 415-423.

  • "Safety of less than 25,000 IU/day of vitamin A in young adults with retinitis pigmentosa." Sibulesky L.;  Hayes K.C.; Pronczuk A.; Weigel-DiFranco C.; Rosner B.; Berson E.L. (1999) Am. J. Clin. Nutr. 69:656-663.

  • "Characterization of the bile acid profile in developing male and female hamsters in response to dietary cholesterol challenge."  Trautwein E.A.; Siddiqui A.; and Hayes K.C. (1999) Comp. Biochem. Physiol. A 124:93-103.

  • “Thermodynamics of interactions between amino acid side chains:  Experimental differentiation of aromatic-aromatic, aromatic-aliphatic and aliphatic-aliphatic side chain interactions in water.” Pereira de Araujo A.F.; Pochapsky T.C.; and Joughin B.) Biophys. J. 76, 2319-2328 (1999).

 

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