Our paper on characterizing the lipid-droplet proteome is published in Current Biology. This collaboration with the Gross laboratory at UC Irvine uncovers a surprising sequestration of certain histones on embryonic lipid droplets in Drosophila. (click here to view article)
Invited speaker, Flyfest: Brian Bettencourt (University of Massachusetts, Lowell): "Population Genomics Of Polyglutamine Expansion In Drosophila: HSP70 As A Selective Agent"
Our paper on Argonaute proteins is published in PLoS Genetics. This collaboration with the Müller laboratory at the University of Düsseldorf demonstrates a role of proteins implicated in RNA silencing for early embryonic development. (click here to view article)
At the Annual Drosophila conference in Houston, TX, the Welte lab presented our progress on five ongoing projects.
- Michael Welte presented a talk on a proteomic analysis of embryonic lipid droplets. This study is a collaboration with Gross laboratory at the University of California, Irvine, and has revealed a new role of lipid droplets as sites to store proteins.
- Graduate student Kim Dae-Hwan presented a poster on the new protein Soft Focus that binds to Klar and is required for normal lipid-droplet transport. This work is a collaboration with Joseph Gindhart's laboratory at the University of Richmond.
- Technician Sean Cotton presented a poster on his work on Klar isoform variation, demonstrating the existence of a new Klar isoform with a special role in nuclear migration.
- Arno Müller (Heinrich-Heine-University, Düsseldorf) presented a talk in the RNA biology workshop how two Argonaute proteins, proteins involved in RNA interference, regulate the midblastula transition, including the directionality of lipid-droplet transport. This work is a collaboration between the Mller and Welte labs.
- Michael Welte presented a poster on the molecular chaperone Hsp70 and how its activity is regulated in a developmentally controlled manner by sequestration.
Our paper on a novel regulator of lipid-droplet transport, LSD2, is published in Current Biology. This collaboration with the Gross laboratory at UC Irvine identifies LSD2 as the first member of a new class of transport regulators, a protein that transduces signals to a separable motor machinery. (click here to view article)
At the Annual Drosophila conference in San Diego, CA, the Welte lab presented updates on five ongoing projects.
- Graduate student Yi Guo presented a poster on distinctly targeted isoforms of Klar.
- Graduate student Susan Tran described the molecular characterization of the directionality determinant Halo.
- Graduate student Kim Dae-Hwan presented a poster on mechanisms that target Klar specifically to lipid droplets. This work is a collaboration with Joseph Gindhart's laboratory at the University of Richmond.
- Wibke Meyer (Heinrich-Heine-University, Düsseldorf) gave a talk on a surprising connection between Argonaute2, a protein involved in RNA interference, and microtubule-based transport in the early embryo, on a joint project between the Müller and Welte labs.
- Amanda Norvell (The College of New Jersey) presented a poster on roles of the Klar protein in oogenesis, a joint project between the Welte and Norvell labs.
Yi Guo's paper on cargo-specific isoforms of the regulator Klar is published in Molecular Biology of the Cell (click here to view article).
Undergraduate Ankit Jain has won a Nathan and Bertha Richter Award for his research project on defining the molecular lesions in several unique klar alleles.
We have started biweekly meetings of the Klar and Halo subgroups, Rosenstiel 3rd floor conference room, on Wednesdays at 11 a.m.
1/12/05
Michael Welte will give his tenure lecture entitled "The Skinny on How I Got Fat: Regulation of Motor-Driven Intracellular Transport" at Brandeis University.
Lab meetings for the spring 2005 will be held on Thursdays from 2:10 to 3:30 p.m. in the Rosenstiel 3rd floor conference room.
Meeting of the American Society of Cell Biology in Washington, D.C.:
- Yi Guo will present a poster on how the general regulator Klar can control transport in an organelle-specific manner.
- Eric Maklan's poster describes expression of the Halo family and the potential role of these proteins in controlling migrating nuclei.
- Silvia Cermelli (University of California, Irvine) will present a poster on a joint project between the Welte and Gross labs on using proteomics approaches to identify regulators of transport.
Invited speaker, Joint Biochemistry/Biology seminar: James R. Sellers (Laboratory of Molecular CardiologyNational Heart, Lung, and Blood Institute NIH): "Myosin V, A Small-Minded Man's Dream"
Invited speaker, Molecular Genetics Journal Club: Francesca Pignoni (Massachusetts Eye and Ear Infirmary, Harvard Medical School): "Control of specification and proliferation in the fly eye-antennal epithelium"
First-year graduate student Heather Stern starts her rotation project.
Wen Song is our current rotator.
Weekly lab meetings for the the Fall 2004 semester will be on Thursday at 2:30 p.m. in the 3rd floor lunch room of the Rosenstiel Center.
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