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The Little Engine Shop is a web page about Jeff Gelles' laboratory in the Department of Biochemistry at Brandeis University. We study motor enzymes, single molecules that perform a function analogous to that of an automobile engine: they "burn" a chemical fuel and use the energy released to perform useful mechanical work. We study these "molecular motors" and other enzymes using the tools of single molecule microscopy. For more information on our current research projects, go to the research section of the site. Publications by the Gelles lab can be found here. The laboratory is also affiliated with the Brandeis graduate program in Biophysics and Structural Biology , the Benjamin & Mae Volen National Center for Complex Systems , and the W.M. Keck Institute for Cellular Visualization.